funding type |
European Comission |
programme |
ERC-2014-ADG |
acronym/
reference |
ATLAS |
alternative reference |
669858 |
research group(s) |
5 - biomedical and biomimetic materials; |
department |
Chemistry (DQ) |
execution dates |
2016-04-01 - 2020-11-30 (
56 Months )
|
abstract/
keywords |
New generations of devices for tissue engineering (TE) should rationalize better the physical and biochemical cues operating in tandem during native regeneration, in particular at the scale/organizational-level of the stem cell niche. The understanding and the deconstruction of these factors (e.g. multiple cell types exchanging both paracrine and direct signals, structural and chemical arrangement of the extra-cellular matrix, mechanical signals…) should be then incorporated into the design of truly biomimetic biomaterials. ATLAS proposes rather unique toolboxes combining smart biomaterials and cells for the ground-breaking advances of engineering fully time-self-regulated complex 2D and 3D devices, able to adjust the cascade of processes leading to faster high-quality new tissue formation with minimum pre-processing of cells. Versatile biomaterials based on marine-origin macromolecules will be used, namely in the supramolecular assembly of instructive multilayers as nanostratified building-blocks for engineer such structures. The backbone of these biopolymers will be equipped with a variety of (bio)chemical elements permitting: post-processing chemistry and micro-patterning, specific/non-specific cell attachment, and cell-controlled degradation. Aiming at being applied in bone TE, ATLAS will integrate cells from different units of tissue physiology, namely bone and hematopoietic basic elements and consider the interactions between the immune and skeletal systems. These ingredients will permit to architect innovative films with high-level dialogue control with cells, but in particular sophisticated quasi-closed 3D capsules able to compartmentalise such components in a “globe-like” organization, providing local and long-range order for in vitro microtissue development and function. Such hybrid devices could be used in more generalised front-edge applications, including as disease models for drug discovery or test new therapies in vitro.
|
coordinator
/local pi |
João Mano |
ciceco status |
Coordinator |
proponent institution |
Universidade de Aveiro (UA) |
partner institution(s) |
no
|
industrial partner(s) |
no |
international partner(s) |
no |
total budget |
2.498.988€
|
ciceco budget |
2.438.987€
|
project code |
3.89.215 |
link |
http://cordis.europa.eu/project/rcn/199773_en.html
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Advanced Bottom-Up Engineering of Living ArchitecturesGaspar, VM; Lavrador, P; Borges, J; Oliveira, MB; Mano, JF 2020, ADVANCED MATERIALS, 32, 6,
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Biomedical applications of laminarinZargarzadeh, M; Amaral, AJR; Custodio, CA; Mano, JF 2020, CARBOHYDRATE POLYMERS, 232,
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Cell Encapsulation Systems Toward Modular Tissue Regeneration: From Immunoisolation to Multifunctional DevicesCorreia, CR; Nadine, S; Mano, JF 2020, ADVANCED FUNCTIONAL MATERIALS, 30, 26,
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Enzymatically degradable, starch-based layer-by-layer films: application to cytocompatible single-cell nanoencapsulationMoon, HC; Han, S; Borges, J; Pesqueira, T; Choi, H; Han, SY; Cho, H; Park, JH; Mano, JF; Choi, IS 2020, SOFT MATTER, 16, 26, 6063-6071.
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Fabrication of Artificial Nanobasement Membranes for Cell Compartmentalization in 3D TissuesZeng, JF; Sasaki, N; Correia, CR; Mano, JF; Matsusaki, M 2020, SMALL, 16, 24,
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Human Platelet Lysates-Based Hydrogels: A Novel Personalized 3D Platform for Spheroid Invasion AssessmentMonteiro, CF; Santos, SC; Custodio, CA; Mano, JF 2020, ADVANCED SCIENCE, 7, 7,
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Mechanochemical Patternable ECM-Mimetic Hydrogels for Programmed Cell OrientationLavrador, P; Gaspar, VM; Mano, JF 2020, ADVANCED HEALTHCARE MATERIALS, 9, 10,
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Multi-layer pre-vascularized magnetic cell sheets for bone regenerationSilva, AS; Santos, LF; Mendes, MC; Mano, JF 2020, BIOMATERIALS, 231,
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Perinatal tissues and cells in tissue engineering and regenerative medicineDeus, IA; Mano, JF; Custodio, CA 2020, ACTA BIOMATERIALIA, 110, 1-14.
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Cell Behavior within Nanogrooved Sandwich Culture SystemsBjorge, IM; Salmeron-Sanchez, M; Correia, CR; Mano, JF 2020, SMALL, 16, 31,
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Hydrogel 3D in vitro tumor models for screening cell aggregation mediated drug responseMonteiro, MV; Gaspar, VM; Ferreira, LP; Mano, JF 2020, BIOMATERIALS SCIENCE, 8, 7, 1855-1864.
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Complex-shaped magnetic 3D cell-based structures for tissue engineeringSantos, LF; Silva, AS; Mano, JF 2020, ACTA BIOMATERIALIA, 118, 18-31.
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Modeling of Cell-Mediated Self-Assembled Colloidal ScaffoldsDias, CS; Custodio, CA; Antunes, GC; da Gama, MMT; Mano, JF; Araujo, NAM 2020, ACS APPLIED MATERIALS & INTERFACES, 12, 43, 48321-48328.
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Dynamic Electrophoretic Assembly of Metal-Phenolic Films: Accelerated Formation and Cytocompatible DetachmentYun, G; Youn, W; Lee, H; Han, SY; Oliveira, MB; Cho, H; Caruso, F; Mano, JF; Choi, IS 2020, CHEMISTRY OF MATERIALS, 32, 18, 7746-7753.
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Geometrically Controlled Liquefied Capsules for Modular Tissue Engineering StrategiesNadine, S; Patricio, SG; Barrias, CC; Choi, IS; Matsusaki, M; Correia, CR; Mano, JF 2020, ADVANCED BIOSYSTEMS, 4, 11,
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Physical immobilization of particles inspired by pollinationSantos, LF; Silva, AS; Correia, CR; Mano, JF 2019, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 116, 12, 5405-5410.
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Liquefied Microcapsules as Dual-Microcarriers for 3D+3D Bottom-Up Tissue EngineeringCorreia, CR; Bjorge, IM; Zeng, JF; Matsusaki, M; Mano, JF 2019, ADVANCED HEALTHCARE MATERIALS, 8, 22,
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Nanogrooved microdiscs for bottom-up modulation of osteogenic differentiationBjorge, IM; Choi, IS; Correia, CR; Mano, JF 2019, NANOSCALE, 11, 35, 16214-16221.
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Screening of perfused combinatorial 3D microenvironments for cell cultureLopes, D; Fernandes, C; Nobrega, JM; Patricio, SG; Oliveira, MB; Mano, JF 2019, ACTA BIOMATERIALIA, 96, 222-236.
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Microparticles in Contact with Cells: From Carriers to Multifunctional Tissue ModulatorsNeto, MD; Oliveira, MB; Mano, JF 2019, TRENDS IN BIOTECHNOLOGY, 37, 9, 1011-1028.
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