Calcium phosphate granules for use as a 5-Fluorouracil delivery system
authors Santos, C; Martins, MA; Franke, RP; Almeida, MM; Costa, MEV
nationality International
journal CERAMICS INTERNATIONAL
author keywords Apatite; Biomedical applications; Spray drying; 5-Fluorouracil
keywords BETA-TRICALCIUM PHOSPHATE; HYDROXYAPATITE PARTICLES; DRUG-DELIVERY; MICROSPHERES; CELLS; NANOPARTICLES; BIOCERAMICS; BONE; FABRICATION; COMPOSITE
abstract The possibility of tailoring apatite granules as a controlled release system for the drug model 5-Fluorouracil (5FU) has been examined. Apatite granules (SDG) were obtained by spray drying suspensions of hydroxyapatite (HAP) nanoparticles previously precipitated from citrate solutions [M.A. Martins, C. Santos, M.E.V. Costa, M.M. Almeida, Preparation of porous hydroxyapatite particles to be used as drug delivery systems, Advanced Materials Forum 11 (455) (2004) 353-357]. SDG had donut shape and very high specific surface area (150 m(2)/g) indicative of high porosity. SDG were. poorly crystalline HAP but turned into biphasic granules (HSDG) with crystalline tricalcium phosphate and HAP after annealing at 800 degrees C, while reducing their surface area down to similar to 6 m(2)/g. SDG and HSDG were soaked in a 5FU solution at pH 5.2 and room temperature during several days and then transferred to a phosphate buffered solution (PBS) at pH 7.4 and 37 degrees C, for releasing 5FU. The comparison between the 5FU adsorbing and releasing behaviours exhibited by SDG and HSDG shows that engineering the granules characteristics, i.e. specific surface area, surface chemical composition, porosity and crystal phase composition allows the 5FU release profile to be controlled. (C) 2008 Elsevier Ltd and Techna Group S.r.l. All rights reserved.
publisher ELSEVIER SCI LTD
issn 0272-8842
year published 2009
volume 35
issue 4
beginning page 1587
ending page 1594
digital object identifier (doi) 10.1016/j.ceramint.2008.08.015
web of science category Materials Science, Ceramics
subject category Materials Science
unique article identifier WOS:000265007200041
  ciceco authors
  impact metrics
times cited (wos core): 15
journal impact factor (jcr 2016): 2.986
5 year journal impact factor (jcr 2016): 2.814
category normalized journal impact factor percentile (jcr 2016): 94.231
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