Hydroxyapatite micro- and nanoparticles: Nucleation and growth mechanisms in the presence of citrate species
authors Martins, MA; Santos, C; Almeida, MM; Costa, MEV
nationality International
journal JOURNAL OF COLLOID AND INTERFACE SCIENCE
author keywords hydroxyapatite; nanoparticles; microparticles; stabilization; aggregation; self-organization
keywords CALCIUM PHOSPHATES; CRYSTALLIZATION; 37-DEGREES-C; DEPENDENCE; PARTICLES; NANORODS; ACID
abstract Hydroxyapatite (HAP) particles with different morphologies were precipitated from homogeneous calcium/citrate/phosphate solutions at physiological temperature. Small variations of the starting solution pH in the range 7.4 < pH < 8.5 made it possible to switch the precipitated particle morphology from a micrometric bundlelike to a nanometric needlelike shape. The role of the existing citrate species as calcium chelates is here discussed within the framework of particle nucleation and growth mechanisms. While temperature-dependent calcium citrate complex (Cacit) stability is here suggested to control the free calcium availability and thereby the nucleation rate, the adsorbed citrate species are proposed to control the nanoparticle stability. Moreover, an attempt to detail the role of citrate species in the ordered aggregation of HAP nuclei leading to the observed peanut and bundlelike microparticles morphology is also presented. (c) 2007 Elsevier Inc. All rights reserved.
publisher ACADEMIC PRESS INC ELSEVIER SCIENCE
issn 0021-9797
year published 2008
volume 318
issue 2
beginning page 210
ending page 216
digital object identifier (doi) 10.1016/j.jcis.2007.10.008
web of science category Chemistry, Physical
subject category Chemistry
unique article identifier WOS:000252482800010
  ciceco authors
  impact metrics
times cited (wos core): 90
journal impact factor (jcr 2016): 4.233
5 year journal impact factor (jcr 2016): 3.988
category normalized journal impact factor percentile (jcr 2016): 76.207
altmetrics:



 


Events
Sponsors

1suponsers_list_ciceco.jpg