Photothermally enhanced drug release by kappa-carrageenan hydrogels reinforced with multi-walled carbon nanotubes
authors Estrada, AC; Daniel-da-Silva, AL; Trindade, T
nationality International
journal RSC ADVANCES
keywords NEAR-INFRARED LIGHT; IN-VITRO; DELIVERY; NANOPARTICLES; SYSTEMS; SINGLE; NANOMATERIALS; IRRADIATION; CHALLENGES; POLYMERS
abstract Temperature and near infrared (NIR) light responsive multi-walled carbon nanotube (MWCNT)-kappa-carrageenan hydrogel composites have been prepared. The effects of the MWCNTs on the microstructure, strength, swelling and release properties of the resultant materials were investigated. MWCNTs acted as reinforcing fillers and enhanced the mechanical properties of the hydrogels, the effect being mostly nanotube concentration dependent. Surface functionalization of nanotubes had a major influence on the swelling of the composites. The increased release of a model drug (methylene blue) in in vitro conditions, from kappa-carrageenan hydrogel composites due to the NIR photothermal effect of MWCNTs was demonstrated at the physiological temperature. Thus, these composites are promising materials for the development of carriers for remotely activated drug delivery.
publisher ROYAL SOC CHEMISTRY
issn 2046-2069
year published 2013
volume 3
issue 27
beginning page 10828
ending page 10836
digital object identifier (doi) 10.1039/c3ra40662h
web of science category Chemistry, Multidisciplinary
subject category Chemistry
unique article identifier WOS:000320467500036
  ciceco authors
  impact metrics
journal impact factor (jcr 2016): 3.108
5 year journal impact factor (jcr 2016): 3.257
category normalized journal impact factor percentile (jcr 2016): 64.759
dimensions (citation analysis):
altmetrics (social interaction):



 


Sponsors

1suponsers_list_ciceco.jpg