Fluorescent Magnetic Bioprobes by Surface Modification of Magnetite Nanoparticles
authors Pinheiro, PC; Daniel-da-Silva, AL; Tavares, DS; Calatayud, MP; Goya, GF; Trindade, T
nationality International
journal MATERIALS
author keywords magnetic nanoparticles; fluorescence; polyelectrolyte; surface functionalization
keywords IRON-OXIDE NANOPARTICLES; DRUG-DELIVERY; BIOMEDICAL APPLICATIONS; INTRACELLULAR UPTAKE; SILICA SPHERES; PARTICLES; LUMINESCENT; CELLS; LAYER
abstract Bimodal nanoprobes comprising both magnetic and optical functionalities have been prepared via a sequential two-step process. Firstly, magnetite nanoparticles (MNPs) with well-defined cubic shape and an average dimension of 80 nm were produced by hydrolysis of iron sulfate and were then surface modified with silica shells by using the sol-gel method. The Fe3O4@SiO2 particles were then functionalized with the fluorophore, fluorescein isothiocyanate (FITC), mediated by assembled shells of the cationic polyelectrolyte, polyethyleneimine (PEI). The Fe3O4 functionalized particles were then preliminary evaluated as fluorescent and magnetic probes by performing studies in which neuroblast cells have been contacted with these nanomaterials.
publisher MDPI AG
issn 1996-1944
year published 2013
volume 6
issue 8
beginning page 3213
ending page 3225
digital object identifier (doi) 10.3390/ma6083213
web of science category Materials Science, Multidisciplinary
subject category Materials Science
unique article identifier WOS:000330293100011

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