Synthesis and biological evaluation of ternary silver compounds bearing N,N-chelating ligands and thiourea: X-ray structure of [{Ag(bpy) (mu-tu)}(2)](NO3)(2) (bpy=2,2 '-bipyridine; tu = thiourea)
authors Segura, DF; Netto, AVG; Frem, RCG; Mauro, AE; da Silva, PB; Fernandes, JA; Paz, FAA; Dias, ALT; Silva, NC; de Almeida, ET; Marques, MJ; de Almeida, L; Alves, KF; Pavan, FR; de Souza, PC; de Barros, HB; Leite, CQF
nationality International
journal POLYHEDRON
author keywords Silver(I); 1,10-Phenanthroline; Antileishmanial activity; Tuberculosis; Antifungal and antibacterial activity
keywords ANTIMICROBIAL ACTIVITIES; CRYSTAL-STRUCTURES; IN-VITRO; SPECTROSCOPIC CHARACTERIZATION; TRIPHENYLPHOSPHINE LIGANDS; MYCOBACTERIUM-TUBERCULOSIS; ANTIMYCOBACTERIAL ACTIVITY; LEISHMANICIDAL ACTIVITY; SUBSTITUTED THIOUREAS; COORDINATION POLYMERS
abstract Compounds [{Ag(phen)(mu-tu)}(2)](NO3)(2) (1), [{Ag(phen)(mu-tu)}(2)](CF3SO3)(2) (2), [{Ag(bpy)(mu-tu)}(2)](NO3)(2) (3) (where phen = 1,10-phenanthroline; bpy = 2,2'-bipyridine; tu = thiourea) were prepared by reacting the appropriate AgX salt (X- = NO3-, CF3SO3-), the N,N-chelating ligand (phen or bpy) and thiourea in a ca. 1:1:2 M ratio, respectively. The silver(l) complexes were characterized by elemental analysis, infrared (IR), H-1 and C-13 NMR spectroscopies, MS/ESI and conductivity measurements. The IR and NMR data were consistent with the presence of chelating phen (1 and 2) and bpy (3) ligands and demonstrated the S-coordination mode of thiourea. The crystal and molecular structures of compound [{Ag(bpy)(mu-tu)}(2)] (NO3)(2) (3) were determined by single-crystal X-ray diffraction. The complexes 1-3 were screened for their in vitro antimycobacterial (Mycobacterium tuberculosis), antileishmanial (Leishmania (L) amazonensis), antibacterial (Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa), antifungal activities (Candida albi cans, Candida tropicalis, Candida krusei). (C) 2014 Elsevier Ltd. All rights reserved.
publisher PERGAMON-ELSEVIER SCIENCE LTD
issn 0277-5387
year published 2014
volume 79
beginning page 197
ending page 206
digital object identifier (doi) 10.1016/j.poly.2014.05.004
web of science category Chemistry, Inorganic & Nuclear; Crystallography
subject category Chemistry; Crystallography
unique article identifier WOS:000340313800023
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