Topical caffeine delivery using biocellulose membranes: a potential innovative system for cellulite treatment
authors Silva, NHCS; Drumond, I; Almeida, IF; Costa, P; Rosado, CF; Neto, CP; Freire, CSR; Silvestre, AJD
nationality International
journal CELLULOSE
author keywords Bacterial cellulose; Cellulite; Caffeine; Topical drug delivery
keywords IN-VITRO DIFFUSION; BACTERIAL CELLULOSE; BIOMATERIALS; FIBROBLASTS; LIDOCAINE; IBUPROFEN; POLYMERS; RELEASE; WOUNDS; SKIN
abstract In this study, biocellulose (BC) membranes have been investigated as caffeine topical delivery systems, for the potential treatment of cellulite. BC-caffeine membranes were prepared by a simple approach and the permeation of caffeine through human epidermis, from BC or from conventional formulation systems (solution and gel), was compared in vitro to assess their therapeutic applicability. Diffusion studies with Franz cells showed that the incorporation of caffeine in BC membranes provided lower permeation rates than those obtained with the conventional formulations. These results combined with the possibility of producing BC membranes with different shapes demonstrate that these materials are promising biosystems for topical delivery of caffeine, showing reproducibility and an extended and predictable caffeine release over time, leading to their potential use for cellulite attenuation.
publisher SPRINGER
issn 0969-0239
year published 2014
volume 21
issue 1
beginning page 665
ending page 674
digital object identifier (doi) 10.1007/s10570-013-0114-1
web of science category Materials Science, Paper & Wood; Materials Science, Textiles; Polymer Science
subject category Materials Science; Polymer Science
unique article identifier WOS:000330807000053

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