Bacterial cellulose membranes as transdermal delivery systems for diclofenac: In vitro dissolution and permeation studies
authors Silva, NHCS; Rodrigues, AF; Almeida, IF; Costa, PC; Rosado, C; Neto, CP; Silvestre, AJD; Freire, CSR
nationality International
journal CARBOHYDRATE POLYMERS
author keywords Bacterial cellulose membranes; Diclofenac sodium; Transdermal delivery; In vitro permeation; Franz cells; Human epidermal membranes
keywords BIOMEDICAL APPLICATIONS; BIOCELLULOSE MEMBRANES; RELEASE; SODIUM; VIVO; NANOCELLULOSE; BIOPOLYMER; LIDOCAINE
abstract Bacterial cellulose (BC) membranes were explored as novel nanostructured transdermal delivery systems for diclofenac sodium salt (a typical non-steroidal anti-inflammatory drug). Diclofenac sodium salt loaded BC membranes were prepared through a simple methodology, using glycerol as plasticizer, and characterized in terms of structure, morphology and swelling behavior. The membranes were very homogeneous, quite flexible and presented a considerably higher swelling behavior when compared with pure BC. In vitro diffusion studies with Franz cells, were conducted using human epidermal membranes, and showed that the incorporation of diclofenac in BC membranes provided similar permeation rates to those obtained with commercial patches and substantially lower than those observed with a commercial gel. This release profile together with the ease of application and the simple preparation and assembly of the drug-loaded membranes clearly indicates the enormous potentialities of using BC membranes for transdermal administration of diclofenac. (C) 2014 Elsevier Ltd. All rights reserved.
publisher ELSEVIER SCI LTD
issn 0144-8617
year published 2014
volume 106
beginning page 264
ending page 269
digital object identifier (doi) 10.1016/j.carbpol.2014.02.014
web of science category Chemistry, Applied; Chemistry, Organic; Polymer Science
subject category Chemistry; Polymer Science
unique article identifier WOS:000335620000035
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journal impact factor 5.158
5 year journal impact factor 5.326
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