Evaluating structural and microstructural changes of PDMS-SiO2 hybrid materials after sterilization by gamma irradiation
authors Almeida, JC; Lancastre, J; Fernandes, MHV; Margaca, FMA; Ferreira, L; Salvado, IMM
nationality International
journal MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
author keywords Sterilization; Gamma irradiation; Hybrid materials; Structure; Microstructure
keywords MODIFIED CAO-SIO2-TIO2 HYBRIDS; NUCLEAR-MAGNETIC-RESONANCE; SI-29 NMR; IN-VITRO; FT-IR; SILOXANE; POLYDIMETHYLSILOXANE; NANOCOMPOSITES; HYDROLYSIS; TEOS
abstract PDMS-SiO2 hybrid materials obtained by sol-gel process have been extensively studied over the past years due to its promising biomedical applications namely as bone substitutes, catheters, and drug delivery devices. Regardless of the intended biomedical application, all these materials should go through a sterilization process before interfacing with a living structure. However, it is unclear whether they undergo structural and microstructural changes when subjected to sterilization by gamma irradiation. This paper addresses this issue by showing that a sol-gel processed biomaterial based on the PDMS-CaO-SiO2 hybrid system suffers only small structural changes when submitted to a radiation dose of 25 kGy, the dose usually recommended to achieve a Sterility Assurance Level of 10(-6) when the natural contamination level and microorganism types cannot be calculated. The characterization was assessed by FT-IR, Si-29-{H-1} CP-MAS, thermal analysis (DTG), and SEM. (C) 2014 Elsevier B.V. All rights reserved.
publisher ELSEVIER SCIENCE BV
issn 0928-4931
year published 2015
volume 48
beginning page 354
ending page 358
digital object identifier (doi) 10.1016/j.msec.2014.12.025
web of science category Materials Science, Biomaterials
subject category Materials Science
unique article identifier WOS:000348749200045
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