Bioactive Triterpenic Acids: From Agroforestry Biomass Residues to Promising Therapeutic Tools
authors Domingues, RMA; Guerra, AR; Duarte, M; Freire, CSR; Neto, CP; Silva, CMS; Silvestre, AJD
nationality International
journal MINI-REVIEWS IN ORGANIC CHEMISTRY
author keywords Antitumoral activity; betulinic acid; biological activity; birch bark; Eucalyptus; oleanolic acid; olive; triterpenic acids; ursolic acid
keywords BREAST-CANCER CELLS; PERFORMANCE LIQUID-CHROMATOGRAPHY; SUPERCRITICAL-FLUID EXTRACTION; EUCALYPTUS-GLOBULUS BARK; MOLECULARLY-IMPRINTED POLYMERS; LIGHT-SCATTERING DETECTION; TETRA-CYCLIC TRITERPENES; POROUS GRAPHITIC CARBON; LIGUSTRUM-LUCIDUM AIT; ANTI-HIV ACTIVITY
abstract This review aims to provide an overview of the biogenetic origin of triterpenic acids (with particular emphasis on ursolic, oleanolic and betulinic acids), on the analytical extraction and hyphenated methodologies (mainly GC-MS) used on their identification and quantification, followed by an overview of the major sources of these components, indicating their potential large scale production pathways, with especial emphasis on abundant agroforestry biomass residues. The biological activity of ursolic, oleanolic and betulinic acids is described, focusing on their antitumoral potential as modulators of growth inhibitory signals, evasion of apoptosis and angiogenesis. The future perspectives towards improved therapeutic strategies using these triterpenic acids are also herein discussed.
publisher BENTHAM SCIENCE PUBL LTD
issn 1570-193X
year published 2014
volume 11
issue 3
beginning page 382
ending page 399
web of science category Chemistry, Organic
subject category Chemistry
unique article identifier WOS:000342282600013
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journal analysis (jcr 2017):
journal impact factor 0.722
5 year journal impact factor 1.075
category normalized journal impact factor percentile 18.421
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