Structure, biodegradation behavior and cytotoxicity of alkali-containing alkaline-earth phosphosilicate glasses
authors Kansal, I; Reddy, A; Munoz, F; Choi, SJ; Kim, HW; Tulyaganov, DU; Ferreira, JMF
nationality International
journal MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
author keywords Alkali; Bioactive glass; Cytotoxicity; Simulated body fluid
keywords FREE BIOACTIVE GLASSES; IN-VITRO; SPECTROSCOPY; ZINC
abstract We report on the effect of sodium on the structure, chemical degradation and bioactivity of glasses in the CaO-MgO-SiO2-P2O5-CaF2 system. The Si-29 and P-31 magic angle spinning-nuclear magnetic resonance spectroscopy of melt-quenched glasses with varying Na2O/MgO ratios exhibit a silicate glass network with the dominance of Q(2)(Si) units and phosphorus mainly forming orthophosphate species. Sodium incorporation in the glasses did not induce a significant structural change in the silicate network, while it did influence the phosphate environment due to its lower ionic field strength in comparison with that of magnesium. The apatite forming ability of glasses has been investigated by immersion of glass powders in simulated body fluid (SBF) for time durations varying between 1 h and 7 days while their chemical degradation has been studied in Tris-HCL in accordance with ISO-10993-14. Increasing Na+/Mg2+ ratio caused a decrease in the chemical durability of glasses and in the apatite forming ability especially during initial steps of interaction between glass and SBF solution. The cellular responses were observed in vitro on bulk glass samples using mouse-derived pre-osteoblastic MC3T3-E1 cell line. The preliminary study suggested that the increasing alkali-concentration in glasses led to cytotoxicity in the cell culture medium. (C) 2014 Elsevier B.V. All rights reserved.
publisher ELSEVIER SCIENCE BV
issn 0928-4931
year published 2014
volume 44
beginning page 159
ending page 165
digital object identifier (doi) 10.1016/j.msec.2014.08.016
web of science category Materials Science, Biomaterials
subject category Materials Science
unique article identifier WOS:000345815400020
link 25280692
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