Calcium Phosphonate Frameworks for Treating Bone Tissue Disorders
authors Shi, FN; Almeida, JC; Helguero, LA; Fernandes, MHV; Knowles, JC; Rocha, J
nationality International
journal INORGANIC CHEMISTRY
keywords OCTACALCIUM PHOSPHATE; PROTON CONDUCTIVITY; APATITE-FORMATION; VITAMIN-D; BISPHOSPHONATES; BIOACTIVITY; MECHANISM; HEALTH; MILK
abstract Two new examples of uncommon three-dimensional Ca-bearing metal organic frameworks, [Ca(H2O)(3)(HPXBP)] (CaP1) and [Ca-2(H2O)(2)(HPXBP)(1.5)] (CaP2) (PXBP: p-xylylenebisphosphonate), were prepared and their structures characterized by single crystal X-ray diffraction. CaP1 crystallizes in the monoclinic C2/c space group, with three water molecules occupying a half coordination sphere on one side of the Ca atom, while CaP2 crystallizes in the triclinic P (1) over bar space group, with two crystallographic unique Ca atoms, each coordinated by a single water molecule. In contrast with CaP2, which exhibits very low bioactivity, CaP1 readily precipitates bone-precursor phases (octacalcium phosphate, OCP, and hydroxyapatite) in SBF solutions. Moreover, studies with MG63 osteoblast-like cells indicate that CaP1 is not toxic and stimulates bone mineralization and, thus, holds considerable potential for treating bone diseases, such as osteoporosis.
publisher AMER CHEMICAL SOC
issn 0020-1669
year published 2015
volume 54
issue 20
beginning page 9929
ending page 9935
digital object identifier (doi) 10.1021/acs.inorgchem.5b01634
web of science category Chemistry, Inorganic & Nuclear
subject category Chemistry
unique article identifier WOS:000363224000034
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journal analysis (jcr 2017):
journal impact factor 4.700
5 year journal impact factor 4.513
category normalized journal impact factor percentile 90.000
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