PDMS-SiO2-TiO2-CaO hybrid materials - Cytocompatibility and nanoscale surface features
authors Almeida, JC; Wacha, A; Gomes, PS; Fernandes, MHR; Fernandes, MHV; Salvado, IMM
nationality International
journal MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
author keywords Sol-gel; Hybrid materials; Hydrophobicity; Cytocompatibility; Bone
keywords NUCLEAR-MAGNETIC-RESONANCE; POLYDIMETHYLSILOXANE (PDMS)-CAO-SIO2 HYBRIDS; MESOPOROUS BIOACTIVE GLASSES; SILOXANE-OXIDE MATERIALS; SMALL-ANGLE SCATTERING; SOL-GEL MATERIALS; X-RAY-SCATTERING; STATE SI-29 NMR; CELL-ADHESION; STRUCTURAL-CHARACTERIZATION
abstract Two PDMS-SiO2-TiO2-Cao porous hybrid materials were prepared using the same base composition, precursors, and solvents, but following two different sol-gel procedures, based on the authors' previous works where for the first time, in this hybrid system, calcium acetate was used as calcium source. The two different procedures resulted in monolithic materials with different structures, microstructures, and surface wettability. Even though both are highly hydrophobic (contact angles of 127.2 degrees and 150.6 degrees), and present different filling regimes due to different surface topographies, they have demonstrated to be-cytocompatible when tested with human osteoblastic cells, against the accepted idea that high-hydrophobic surfaces are not suitable to cell adhesion and proliferation. At the nanoscale, the existence of hydrophilic silica domains containing calcium, where water molecules are physisorbed, is assumed to support this capability, as discussed. (C) 2016 Elsevier B.V. All rights reserved.
publisher ELSEVIER SCIENCE BV
issn 0928-4931
year published 2016
volume 64
beginning page 74
ending page 86
digital object identifier (doi) 10.1016/j.msec.2016.03.071
web of science category Materials Science, Biomaterials
subject category Materials Science
unique article identifier WOS:000376547700009
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