Prospective pathway for a green and enhanced friedelin production through supercritical fluid extraction of Quercus cerris cork
authors Sen, A; de Melo, MMR; Silvestre, AJD; Pereira, H; Silva, CM
nationality International
journal JOURNAL OF SUPERCRITICAL FLUIDS
author keywords Cork; Friedelin; Modeling; Quercus cerris; Supercritical fluid extraction
keywords EUCALYPTUS-GLOBULUS BARK; RESPONSE-SURFACE METHODOLOGY; TRITERPENIC ACIDS; CHEMICAL-COMPOSITION; CARBON-DIOXIDE; BY-PRODUCTS; EXPERIMENTAL-DESIGN; SUBER L.; CO2; OPTIMIZATION
abstract Supercritical fluid extraction (SFE) was applied for the first time to Quercus cerris cork, and compared with Soxhlet with dichloromethane (DCM). Novel triterpenes, viz. betulin and squalene, and beta-sitosterol were identified for the first time in the lipophilic extracts. The SFE at 300 bar and 40-80 degrees C provided extracts much richer in friedelin-the major compound from both SFE and DCM extracts - with concentrations up to 40.6 wt%, against 26.0 wt% for DCM. The SFE yields ranged between 0.97 and 1.81 wt% with pure CO2, and attained 2.83 wt% when ethanol was introduced as cosolvent (10 wt%). In this case, however, the friedelin concentration dropped significantly due to the additional removal of non-target compounds. In general, the experimental data and their trends were in accordance with the theoretical predictions of kinetic and equilibrium properties estimated in this work for the friedelin/SC-CO2 system. This study demonstrates that the SFE of Q cerris cork arises as a prospective pathway for a green and enhanced friedelin production process under the biorefinery concept. (C) 2014 Elsevier B.V. All rights reserved.
publisher ELSEVIER SCIENCE BV
issn 0896-8446
year published 2015
volume 97
beginning page 247
ending page 255
digital object identifier (doi) 10.1016/j.supflu.2014.12.008
web of science category Chemistry, Physical; Engineering, Chemical
subject category Chemistry; Engineering
unique article identifier WOS:000348952800029
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journal impact factor (jcr 2016): 2.991
5 year journal impact factor (jcr 2016): 2.842
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