Synthesis and in vitro bioactivity assessment of injectable bioglass - organic pastes for bone tissue repair
authors Tulyaganov, DU; Reddy, AA; Siegel, R; Ionescu, E; Riedel, R; Ferreira, JMF
nationality International
journal CERAMICS INTERNATIONAL
author keywords Bioactive glasses; Organic carriers; XRD; SEM; Bone grafts
keywords CAO-MGO-SIO2 SYSTEM; GLASS-CERAMICS; STRUCTURAL-ANALYSIS; P2O5 ADDITIVES; COMPOSITES; CAF2; B2O3; NA2O; HYDROXYAPATITE; NANOCOMPOSITES
abstract The aim of this work was to study the bioactivity of systems based on a clinically tested bioactive glass (BG) particulates (mol%: 4.33 Na2O -30.30 CaO -12.99 MgO -45.45 SiO2 -2.60 P2O5 -4.33 CaF2) and organic carriers. The cohesiveness of injectable bone graft products is of high relevance when filling complex volumetric bone defects. With this motivation behind, BG particulates with mean sizes within 11-14 mu m were mixed in different proportions with glycerol (G) and polyethylene glycol (PEG) as organic carriers and the mixtures were fully injectable exhibiting Newtonian flow behaviors. The apatite forming ability was investigated using X-ray diffraction and field emission scanning electron microscopy under secondary electron mode after immersion of samples in simulated body fluid (SBF) for time durations varying between 12 h and 7 days. The results obtained revealed that in spite of the good adhesion of glycerol and PEG carriers to glass particles during preparation stage, they did not hinder the exposure of bioactive glass particulates to the direct contact with SBF solution. The results confirmed the excellent bioactivity in vitro for all compositions expressed by high biomineralization rates with the formation of crystalline hydroxyapatite being identified by XRD after 12 h of immersion in SBF solution. (C) 2015 Elsevier Ltd and Techna Group S.r.l. All rights reserved.
publisher ELSEVIER SCI LTD
issn 0272-8842
year published 2015
volume 41
issue 8
beginning page 9373
ending page 9382
digital object identifier (doi) 10.1016/j.ceramint.2015.03.312
web of science category Materials Science, Ceramics
subject category Materials Science
unique article identifier WOS:000356549100019
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