Storage and delivery of nitric oxide by microporous titanosilicate ETS-10 and Al and Ga substituted analogues
authors Pinto, ML; Fernandes, AC; Antunes, F; Pires, J; Rocha, J
nationality International
journal MICROPOROUS AND MESOPOROUS MATERIALS
author keywords Nitric oxide; Titanosilicate; NO release; Toxicity; Adsorption
keywords HELA CANCER-CELLS; DRUG-DELIVERY; SLOW-RELEASE; ZEOLITE STRUCTURES; SURFACE-PROPERTIES; NANOPARTICLES; CYTOTOXICITY; ADSORPTION; NO; AVOIDANCE
abstract Exogenous administration of nitric oxide may be a therapy for several pathologies because this molecule regulates many biological systems. Here, the storage and release of NO by microporous titanosilicate ETS-10 and samples where the silicon was substituted by aluminium (ETAS-10) or gallium (ETGS-10) are studied. The Al- and Ga-doped materials exhibit an increase in the storage capacity of 95% and 55%, respectively, the highest values observed, so far, for microporous titanosilicates. ETAS-10 releases more NO and ETGS-10 almost the same amount as ETS-10. In ETAS-10 and ETGS-10, the irreversibly adsorbed NO amount increases relatively to ETS-10. Tests of NO release in haemoglobin solutions indicate that biologically relevant amounts are release and that ETS-10 and ETGS-10 display a release slower than ETAS-10, more adequate for a sustained delivery. Cytotoxicity studies show that the samples have very low toxicity (cell viability above 87%, after 72 h) at high concentration (0.45 mg cm(-3)). Tests at variable ETS-10 concentration further confirm the low cytotoxicity of this material, even at high concentrations (up to 1.8 mg cm(-3)). (C) 2016 Elsevier Inc. All rights reserved.
publisher ELSEVIER SCIENCE BV
issn 1387-1811
year published 2016
volume 229
beginning page 83
ending page 89
digital object identifier (doi) 10.1016/j.micromeso.2016.04.021
web of science category Chemistry, Applied; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary
subject category Chemistry; Science & Technology - Other Topics; Materials Science
unique article identifier WOS:000377733100011
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