Targeting Cancer Cells with Photoactive Silica Nanoparticles
authors Borzecka, W; Trindade, T; Torres, T; Tome, J
nationality International
journal CURRENT PHARMACEUTICAL DESIGN
author keywords Porphyrins; Phthalocyanines; Photosensitizers; Silica Nanoparticles; PDT; Cancer
keywords THERAPY IN-VITRO; UP-CONVERSION NANOPARTICLES; SINGLET OXYGEN GENERATION; IRON-OXIDE NANOPARTICLES; PHOTODYNAMIC THERAPY; DRUG-DELIVERY; PHOTOPHYSICAL PROPERTIES; BIOMEDICAL APPLICATIONS; COMBINED CHEMOTHERAPY; HYBRID NANOPARTICLES
abstract This review highlights recent advances in the preparation of silica nanoparticles (SNPs) functionalized with porphyrins and phthalocyanines for application in cancer photo-diagnostic and photodynamic therapy (PDT). The use of photosensitizer-SNP formulations has emerged recently as a new nanomedicine for cancer research owing to their unique physicochemical properties, which make them useful for photo-biomedical applications. In order to study their photobiological properties, diverse chemical strategies involving covalent and non-covalent bonding have been used to load photosensitizers in/on SNPs.
publisher BENTHAM SCIENCE PUBL LTD
issn 1381-6128
year published 2016
volume 22
issue 39
beginning page 6021
ending page 6038
digital object identifier (doi) 10.2174/1381612822666160614083804
web of science category Pharmacology & Pharmacy
subject category Pharmacology & Pharmacy
unique article identifier WOS:000390650400013
  ciceco authors
  impact metrics
times cited (wos core): 2
journal impact factor (jcr 2016): 2.611
5 year journal impact factor (jcr 2016): 3.000
category normalized journal impact factor percentile (jcr 2016): 54.492
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