The role of surface functionalization of silica nanoparticles for bioimaging
authors Gomes, MC; Cunha, A; Trindade, T; Tome, JPC
nationality International
journal JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES
author keywords Fluorescent silica nanoparticles; bioimaging; surface functionalization; nanoparticle-cell interactions
keywords TARGETED DRUG-DELIVERY; PHOTODYNAMIC THERAPY; LANTHANIDE COMPLEXES; IN-VIVO; CONTROLLED-RELEASE; AMINO-ACIDS; FLUORESCENT NANOPARTICLES; BIOMEDICAL APPLICATIONS; EUROPIUM NANOPARTICLES; IMAGING APPLICATIONS
abstract Among the several types of inorganic nanoparticles available, silica nanoparticles (SNP) have earned their relevance in biological applications namely, as bioimaging agents. In fact, fluorescent SNP (FSNP) have been explored in this field as protective nanocarriers, overcoming some limitations presented by conventional organic dyes such as high photobleaching rates. A crucial aspect on the use of fluorescent SNP relates to their surface properties, since it determines the extent of interaction between nanoparticles and biological systems, namely in terms of colloidal stability in water, cellular recognition and internalization, tracking, biodistribution and specificity, among others. Therefore, it is imperative to understand the mechanisms underlying the interaction between biosystems and the SNP surfaces, making surface functionalization a relevant step in order to take full advantage of particle properties. The versatility of the surface chemistry on silica platforms, together with the intrinsic hydrophilicity and biocompatibility, make these systems suitable for bioimaging applications, such as those mentioned in this review.
publisher WORLD SCIENTIFIC PUBL CO PTE LTD
issn 1793-5458
year published 2016
volume 9
issue 4
digital object identifier (doi) 10.1142/S1793545816300056
web of science category Optics; Radiology, Nuclear Medicine & Medical Imaging
subject category Optics; Radiology, Nuclear Medicine & Medical Imaging
unique article identifier WOS:000379752500002
  ciceco authors
  impact metrics
times cited (wos core): 2
journal impact factor (jcr 2016): 1.120
5 year journal impact factor (jcr 2016): 1.000
category normalized journal impact factor percentile (jcr 2016): 23.978
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