Antimicrobial activity of 2-mercaptobenzothiazole released from environmentally friendly nanostructured layered double hydroxides
authors Kuznetsova, A; Domingues, PM; Silva, T; Almeida, A; Zheludkevich, ML; Tedim, J; Ferreira, MGS; Cunha, A
nationality International
journal JOURNAL OF APPLIED MICROBIOLOGY
author keywords antimicrobials; bioluminescence; immobilized biocides; nanomaterials; triggered release
keywords ESCHERICHIA-COLI; INTERCALATION; NANOCONTAINERS; NANOCAPSULES; TOXICITY; COATINGS
abstract AimsThe objective of this work was to assess the antibacterial effect of 2-mercaptobenzothiazole (MBT), used as model-biocide, immobilized in a layered double hydroxide (LDH) structure, under different conditions of pH and salinity, envisaging possible applications of the system in active antifouling and anticorrosion coatings. Methods and ResultsBiological effects of MBT immobilized in LDH were assessed by monitoring bacterial bioluminescence of cell suspensions of either Allivibrio fischeri or a recombinant strain of Escherichia coli, as a proxy for bacterial activity. Salinity (1, 2 and 3% NaCl) and pH (4, 5, 6 and 7) of the suspension media were experimentally manipulated and biocide release tests were performed in parallel. The release profiles obtained by UV-visible spectrophotometry indicated a fast release of biocide from MBT@LDH, slightly enhanced in 3% NaCl and under alkaline conditions. However, biological effects were more pronounced at 1% NaCl and at neutral pH. ConclusionsThe release and toxic effect of MBT immobilized in LDH is dependent on the concentration of solutes in the suspension medium. Significance and Impact of the StudyThe results confirm LDH as a biologically compatible material with potential to be used for biocide delivery.
publisher WILEY
issn 1364-5072
year published 2017
volume 122
issue 5
beginning page 1207
ending page 1218
digital object identifier (doi) 10.1111/jam.13433
web of science category Biotechnology & Applied Microbiology; Microbiology
subject category Biotechnology & Applied Microbiology; Microbiology
unique article identifier WOS:000398853500009
  ciceco authors
  impact metrics
times cited (wos core): 0
journal impact factor (jcr 2016): 2.099
5 year journal impact factor (jcr 2016): 2.619
category normalized journal impact factor percentile (jcr 2016): 44.311
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