|
authors |
Cardoso, MFD; Gomes, ATPC; Moreira, CD; Simoes, MMQ; Neves, MGPMS; da Rocha, DR; da Silva, FD; Moreirinha, C; Almeida, A; Ferreira, VF; Cavaleiro, JAS |
|
nationality |
International |
|
journal |
MOLECULES |
|
author keywords |
oxidation; porphyrinatoMn(III); hydrogen peroxide; arylthio; cyclohexylthio-lapachones; sulfonyl-lapachones; polyvinylpyrrolidone; antibacterial activity |
|
keywords |
TRYPANOSOMA-CRUZI ACTIVITY; NOR-BETA-LAPACHONE; ORGANOSULFUR COMPOUNDS; ANTITUMOR-ACTIVITY; NAPHTHOQUINONES; COMPLEXES; AGENTS; PORPHYRINS; PARAMETERS; DELIVERY |
|
abstract |
New sulfonyl-lapachones were efficiently obtained through the catalytic oxidation of arylthio- and cyclohexylthio-lapachone derivatives with hydrogen peroxide in the presence of a Mn(III) porphyrin complex. The antibacterial activities of the non-oxidized and oxidized lapachone derivatives against the Gram-negative bacteria Escherichia coli and the Gram-positive bacteria Staphylococcus aureus were evaluated after their incorporation into polyvinylpyrrolidone (PVP) micelles. The obtained results show that the PVP-formulations of the lapachones 4b-g and of the sulfonyl-lapachones 7e and 7g reduced the growth of S. aureus. |
|
publisher |
MDPI AG |
|
issn |
1420-3049 |
|
year published |
2017 |
|
volume |
22 |
|
issue |
2 |
|
digital object identifier (doi) |
10.3390/molecules22020302 |
|
web of science category |
Chemistry, Organic |
|
subject category |
Chemistry |
|
unique article identifier |
WOS:000395552400116
|
