Osteogenic capacity of alkali-free bioactive glasses. In vitro studies
authors Brito, AF; Antunes, B; dos Santos, F; Fernandes, HR; Ferreira, JMF
nationality International
journal JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
author keywords alkali-free bioactive glasses; 45S5 Bioglass((R)); hMSCs; proliferation; differentiation
keywords MESENCHYMAL STROMAL CELLS; PHOSPHOSILICATE GLASSES; ZINC; STRONTIUM; BEHAVIOR; BIODEGRADATION
abstract The high alkali content bioactive glasses commonly used to regenerate bone in dental, orthopedic, and maxillofacial surgeries induce some cytotoxicity in surrounding tissues. The present study aims the ability of some alkali-free bioactive glasses compositions, recently developed by our research group, to stimulate human mesenchymal stem cells (hMSCs) differentiation into osteoblasts in comparison to 45S5 Bioglass((R)). The obtained results demonstrated that alkali-free bioactive glasses possess higher stimulating towards differentiation of hMSCs in comparison to the control 45S5 Bioglass((R)). The von Kossa assay demonstrated that all bioactive glasses studied were able to induce the appearance of calcium deposits even when the cells were cultured in DMEM, proving that these biomaterials per se induce hMSCs cell differentiation. It was also observed that in both cell culture medium used (DMEM, and osteogenesis differentiation medium) alkali-free bioactive glasses clearly induced the appearance of more calcium deposits than the 45S5 Bioglass((R)), indicating their greater ability to induce cell differentiation. In summary, these results indicate that alkali-free bioactive glasses are a safe and valid alternative to 45S5 Bioglass((R)). (C) 2016 Wiley Periodicals, Inc.
publisher WILEY
issn 1552-4973
year published 2017
volume 105
issue 8
beginning page 2360
ending page 2365
digital object identifier (doi) 10.1002/jbm.b.33771
web of science category Engineering, Biomedical; Materials Science, Biomaterials
subject category Engineering; Materials Science
unique article identifier WOS:000412194200018
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journal analysis (jcr 2017):
journal impact factor 3.373
5 year journal impact factor 3.104
category normalized journal impact factor percentile 68.969
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