Bioactivity and antibacterial activity against E-coli of calcium-phosphate-based glasses: Effect of silver content and crystallinity

authors	Capela, MN; Tobaldi, DM; Oliveira, C; Pereira, A; Duarte, AS; Seabra, MP; Fernandes, MHV
nationality	International
journal	CERAMICS INTERNATIONAL
author keywords	Glass; Glass-ceramic; Bioactive; Silver; Antibacterial
keywords	BOROSILICATE GLASSES; DISSOLUTION; BACTERIA
abstract	In this work we developed improved bioactive glasses and glass-ceramics for biomedical applications, investigating their in vitro bioactivity, biocompatibility and antibacterial properties against E-Coli. A melt-quenched bioactive glass of the SiO2-CaO-P2O5-MgO system was modified with the addition of 1 and 2 mol% Ag2O and the 1 mol% Ag2O-containing glasses were then heat treated to produce glass-ceramics. Surface modifications after soaking in SBF and ionic concentration changes showed that addition of silver and crystallization did not affect bioactivity although crystalline phases promoted a decrease in the degradation rate. Biocompatibility of all Ag-containing glasses and glass-ceramics was confirmed for certain samples concentrations. The antibacterial activity of the glasses against E-Coli was generally improved with decreasing particle size or increasing Ag2O. The Ag-containing glass-ceramics with higher content of crystalline phase appears as a promising biocompatible biocidal material with potential applications in bone-related diseases.
publisher	ELSEVIER SCI LTD
issn	0272-8842
year published	2017
volume	43
issue	16
beginning page	13800
ending page	13809
digital object identifier (doi)	10.1016/j.ceramint.2017.07.100
web of science category	Materials Science, Ceramics
subject category	Materials Science
unique article identifier	WOS:000411299300098