authors |
Capela, MN; Tobaldi, DM; Oliveira, C; Pereira, A; Duarte, AS; Seabra, MP; Fernandes, MHV |
nationality |
International |
journal |
CERAMICS INTERNATIONAL |
author keywords |
Glass; Glass-ceramic; Bioactive; Silver; Antibacterial |
keywords |
BOROSILICATE GLASSES; DISSOLUTION; BACTERIA |
abstract |
In this work we developed improved bioactive glasses and glass-ceramics for biomedical applications, investigating their in vitro bioactivity, biocompatibility and antibacterial properties against E-Coli. A melt-quenched bioactive glass of the SiO2-CaO-P2O5-MgO system was modified with the addition of 1 and 2 mol% Ag2O and the 1 mol% Ag2O-containing glasses were then heat treated to produce glass-ceramics. Surface modifications after soaking in SBF and ionic concentration changes showed that addition of silver and crystallization did not affect bioactivity although crystalline phases promoted a decrease in the degradation rate. Biocompatibility of all Ag-containing glasses and glass-ceramics was confirmed for certain samples concentrations. The antibacterial activity of the glasses against E-Coli was generally improved with decreasing particle size or increasing Ag2O. The Ag-containing glass-ceramics with higher content of crystalline phase appears as a promising biocompatible biocidal material with potential applications in bone-related diseases. |
publisher |
ELSEVIER SCI LTD |
issn |
0272-8842 |
year published |
2017 |
volume |
43 |
issue |
16 |
beginning page |
13800 |
ending page |
13809 |
digital object identifier (doi) |
10.1016/j.ceramint.2017.07.100 |
web of science category |
Materials Science, Ceramics |
subject category |
Materials Science |
unique article identifier |
WOS:000411299300098
|