Removal of Nonsteroidal Anti-Inflammatory Drugs from Aqueous Environments with Reusable Ionic-Liquid-Based Systems
authors Almeida, HFD; Marrucho, IM; Freire, MG
nationality International
journal ACS SUSTAINABLE CHEMISTRY & ENGINEERING
author keywords Active pharmaceutical ingredients; Removal; Wastewater treatment plants; Aqueous biphasic systems; Ionic liquids; Extraction efficiency; Recovery
keywords WASTE-WATER TREATMENT; PERSONAL CARE PRODUCTS; ENDOCRINE DISRUPTING COMPOUNDS; BIPHASIC SYSTEMS; TREATMENT PLANTS; AQUATIC ENVIRONMENT; DRINKING-WATER; PHARMACEUTICAL RESIDUES; EMERGING CONTAMINANTS; 2-PHASE SYSTEM
abstract In the current era of human life, we face an increased consumption of nonsteroidal anti-inflammatory drugs (NSAIDs). Nevertheless, NSAIDs are not entirely metabolized by humans and are thus excreted into domestical effluents, whereas expired medications are recurrently directly disposed into wastewaters. Several studies have already demonstrated that an extensive diversity of pharmaceuticals is present in aqueous effluents and is therefore a matter of serious concern with regard to wildlife and public health. In this perspective, this work is focused on the use of a liquid liquid extraction approach for the removal of NSAIDs from aqueous media. In particular, aqueous biphasic systems (ABS) composed of ionic liquids (ILs) and aluminum-based salts were used for the removal of diclofenac, ibuprofen, naproxen, and ketoprofen. With these systems, extraction efficiencies of NSAIDs up to 100% into the IL-rich phase were obtained in a single-step. Further, the recovery of NSAIDs from the IL medium and the recyclability of the IL-rich phase were ascertained aiming at developing a more sustainable and cost-effective strategy. On the basis of the remarkable increase of the NSAIDs solubility in the IL-rich phase (from 300- to 4100-fold when compared with pure water), water was used as an effective antisolvent, where recovery percentages of NSAIDs from the IL-rich phase up to 91% were obtained. After the "cleaning" of the IL-rich phase by the induced precipitation of NSAIDs, the phase-forming components were recovered and reused in four consecutive cycles, with no detected losses on both the extraction efficiency and recovery of NSAIDs.
publisher AMER CHEMICAL SOC
issn 2168-0485
year published 2017
volume 5
issue 3
beginning page 2428
ending page 2436
digital object identifier (doi) 10.1021/acssuschemeng.6b02771
web of science category Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Chemical
subject category Chemistry; Science & Technology - Other Topics; Engineering
unique article identifier WOS:000395846900047
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journal analysis (jcr 2019):
journal impact factor 7.632
5 year journal impact factor 7.741
category normalized journal impact factor percentile 90.792
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