The Key Role of Sulfation and Branching on Fucoidan Antitumor Activity
authors Oliveira, C; Ferreira, AS; Novoa-Carballal, R; Nunes, C; Pashkuleva, I; Neves, NM; Coimbra, MA; Reis, RL; Martins, A; Silva, TH
nationality International
journal MACROMOLECULAR BIOSCIENCE
author keywords antitumor activity; fucoidan; polymer branching; structure-activity relationship; sulfation
keywords MOLECULAR-WEIGHT FUCOIDAN; ANTICANCER ACTIVITY; CANCER-CELLS; UNDARIA-PINNATIFIDA; IN-VITRO; POLYSACCHARIDES; BIOACTIVITY; HYDROLYSIS; VIABILITY; CARCINOMA
abstract There is an urgent need for antitumor bioactive agents with minimal or no side effects over normal adjacent cells. Fucoidan is a marine-origin polymer with known antitumor activity. However, there are still some concerns about its application due to the inconsistent experimental results, specifically its toxicity over normal cells and the mechanism behind its action. Herein, three fucoidan extracts (FEs) have been tested over normal and breast cancer cell lines. From cytotoxicity results, only one of the extracts shows selective antitumor behavior (at 0.2 mg mL(-1)), despite similarities in sulfation degree and carbohydrates composition. Although the three FEs present different molecular weights, depolymerization of selected samples discarded M-w as the key factor in the antitumor activity. Significant differences in sulfates position and branching are observed, presenting FE 2 the higher branching degree. Based on all these experimental data, it is believed that these last two properties are the ones that influence the cytotoxic effects of fucoidan extracts.
publisher WILEY-V C H VERLAG GMBH
issn 1616-5187
year published 2017
volume 17
issue 5
digital object identifier (doi) 10.1002/mabi.201600340
web of science category Biochemistry & Molecular Biology; Materials Science, Biomaterials; Polymer Science
subject category Biochemistry & Molecular Biology; Materials Science; Polymer Science
unique article identifier WOS:000404298200015
  ciceco authors
  impact metrics
times cited (wos core): 4
journal impact factor (jcr 2016): 3.238
5 year journal impact factor (jcr 2016): 3.491
category normalized journal impact factor percentile (jcr 2016): 68.100
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