Eucalyptus spp. outer bark extracts inhibit Helicobacter pylori growth: in vitro studies
authors Parreira, P; Soares, BIG; Freire, CSR; Silvestre, AJD; Reis, CA; Martins, MCL; Duarte, MF
nationality International
journal INDUSTRIAL CROPS AND PRODUCTS
author keywords Helicobacter pylori; Phytotherapy; Eucalyptus spp. outer bark lipophilic extracts; Triterpenic acids
keywords PENTACYCLIC TRITERPENES; ANTIMICROBIAL ACTIVITY; PLANT-EXTRACTS; ANTIBACTERIAL ACTIVITY; BIOMASS RESIDUES; NATURAL-PRODUCTS; GASTRIC-CANCER; INFECTION; ACIDS; GLYCOSYLATION
abstract Helicobacter pylori is the etiologic agent of several gastric disorders. The growing rates of unsuccessfulness of available antibiotics-based therapy led to the need for non-antibiotic compounds for H. pylori treatment. The antibacterial activity of Eucalyptus nitens and Eucalyptus globulus outer bark lipophilic extracts were evaluated against a panel of H. pylori strains, as well as the role of pure triterpenic acids and synthetic mixtures mimicking the natural extracts. Best results were obtained with E. nitens outer bark extract (MIC = 64 mu g/mL) and it was demonstrated that after 6 h of exposure to the MIC, there was a significant decrease ( > 50%) in H. pylori growth. Moreover, it was determined that the antibacterial effect of Eucalyptus spp. outer bark extracts was due to the synergetic effect of four triterpenic acids, namely betulinic, betulonic, ursolic and oleanolic acids. Our findings open new perspectives for development of anti-H. pylori therapies based on the use of these plant extracts.
publisher ELSEVIER SCIENCE BV
issn 0926-6690
isbn 1872-633X
year published 2017
volume 105
beginning page 207
ending page 214
digital object identifier (doi) 10.1016/j.indcrop.2017.05.012
web of science category Agricultural Engineering; Agronomy
subject category Agriculture
unique article identifier WOS:000403637000022
  ciceco authors
  impact metrics
times cited (wos core): 0
journal impact factor (jcr 2016): 3.181
5 year journal impact factor (jcr 2016): 3.577
category normalized journal impact factor percentile (jcr 2016): 85.349
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