Bioglass implant-coating interactions in synthetic physiological fluids with varying degrees of biomimicry
authors Popa, AC; Stan, GE; Husanu, MA; Mercioniu, I; Santos, LF; Fernandes, HR; Ferreira, JMF
nationality International
journal INTERNATIONAL JOURNAL OF NANOMEDICINE
author keywords biomaterials; bioglass; in vitro biomimetic assays; proteins
keywords SIMULATED BODY-FLUID; IN-VITRO BIOACTIVITY; DRUG-RELEASE PROPERTY; THIN-FILMS; PROTEIN ADSORPTION; APATITE-FORMATION; MECHANICAL-PROPERTIES; DISSOLUTION BEHAVIOR; BONE REGENERATION; LOW-TEMPERATURE
abstract Synthetic physiological fluids are currently used as a first in vitro bioactivity assessment for bone grafts. Our understanding about the interactions taking place at the fluid-implant interface has evolved remarkably during the last decade, and does not comply with the traditional International Organization for Standardization/final draft International Standard 23317 protocol in purely inorganic simulated body fluid. The advances in our knowledge point to the need of a true paradigm shift toward testing physiological fluids with enhanced biomimicry and a better understanding of the materials' structure-dissolution behavior. This will contribute to "upgrade" our vision of entire cascades of events taking place at the implant surfaces upon immersion in the testing media or after implantation. Starting from an osteoinductive bioglass composition with the ability to alleviate the oxidative stress, thin bioglass films with different degrees of polymerization were deposited onto titanium substrates. Their biomineralization activity in simulated body fluid and in a series of new inorganic-organic media with increasing biomimicry that more closely simulated the human intercellular environment was compared. A comprehensive range of advanced characterization tools (scanning electron microscopy; grazing-incidence X-ray diffraction; Fourier-transform infrared, micro-Raman, energy-dispersive, X-ray photoelectron, and surface-enhanced laser desorption/ionization time-of-flight mass spectroscopies; and cytocompatibility assays using mesenchymal stem cells) were used. The information gathered is very useful to biologists, biophysicists, clinicians, and material scientists with special interest in teaching and research. By combining all the analyses, we propose herein a step forward toward establishing an improved unified protocol for testing the bioactivity of implant materials.
publisher DOVE MEDICAL PRESS LTD
issn 1178-2013
year published 2017
volume 12
beginning page 683
ending page 707
digital object identifier (doi) 10.2147/IJN.S123236
web of science category Nanoscience & Nanotechnology; Pharmacology & Pharmacy
subject category Science & Technology - Other Topics; Pharmacology & Pharmacy
unique article identifier WOS:000392324700001
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  impact metrics
times cited (wos core): 1
journal impact factor (jcr 2016): 4.300
5 year journal impact factor (jcr 2016): 5.008
category normalized journal impact factor percentile (jcr 2016): 76.492
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