The Potential of Liquid Marbles for Biomedical Applications: A Critical Review
authors Oliveira, NM; Reis, RL; Mano, JF
nationality International
journal ADVANCED HEALTHCARE MATERIALS
author keywords biomedical applications; freestanding droplets; liquid marbles; soft solids
keywords SUPERHYDROPHOBIC SURFACE; SILICA NANOPARTICLES; FE3O4 NANOPARTICLES; POLYMER LATEXES; SELF-PROPULSION; WATER DROPLETS; PARTICLES; DROPS; EVAPORATION; CELLS
abstract Liquid marbles (LM) are freestanding droplets covered by micro/nanoparticles with hydrophobic/hydrophilic properties, which can be manipulated as a soft solid. The phenomenon that generates these soft structures is regarded as a different method to generate a superhydrophobic behavior in the liquid/solid interface without modifying the surface. Several applications for the LM have been reported in very different fields, however the developments for biomedical applications are very recent. At first, the LM properties are reviewed, namely shell structure, LM shape, evaporation, floatability and robustness. The different strategies for LM manipulation are also described, which make use of magnetic, electrostatic and gravitational forces, ultraviolet and infrared radiation, and approaches that induce LM self-propulsion. Then, very distinctive applications for LM in the biomedical field are presented, namely for diagnostic assays, cell culture, drug screening and cryopreservation of mammalian cells. Finally, a critical outlook about the unexplored potential of LM for biomedical applications is presented, suggesting possible advances on this emergent scientific area.
publisher WILEY
issn 2192-2640
isbn 2192-2659
year published 2017
volume 6
issue 19
digital object identifier (doi) 10.1002/adhm.201700192
web of science category Engineering, Biomedical; Nanoscience & Nanotechnology; Materials Science, Biomaterials
subject category Engineering; Science & Technology - Other Topics; Materials Science
unique article identifier WOS:000412752400001
  ciceco authors
  impact metrics
times cited (wos core): 1
journal impact factor (jcr 2016): 5.110
5 year journal impact factor (jcr 2016): 5.454
category normalized journal impact factor percentile (jcr 2016): 85.602
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