Nanoengineering Hybrid Supramolecular Multilayered Biomaterials Using Polysaccharides and Self-Assembling Peptide Amphiphiles
authors Borges, J; Sousa, MP; Cinar, G; Caridade, SG; Guler, MO; Mano, JF
nationality International
journal ADVANCED FUNCTIONAL MATERIALS
keywords QUARTZ-CRYSTAL MICROBALANCE; POLYELECTROLYTE MULTILAYERS; BIOMEDICAL APPLICATIONS; SECONDARY STRUCTURE; POLYMER-FILMS; OSTEOGENIC DIFFERENTIATION; INFRARED-SPECTROSCOPY; REGENERATIVE MEDICINE; CIRCULAR-DICHROISM; SURFACE INTERFACE
abstract Developing complex supramolecular biomaterials through highly dynamic and reversible noncovalent interactions has attracted great attention from the scientific community aiming key biomedical and biotechnological applications, including tissue engineering, regenerative medicine, or drug delivery. In this study, the authors report the fabrication of hybrid supramolecular multilayered biomaterials, comprising high-molecular-weight biopolymers and oppositely charged low-molecular-weight peptide amphiphiles (PAs), through combination of self-assembly and electrostatically driven layer-by-layer (LbL) assembly approach. Alginate, an anionic polysaccharide, is used to trigger the self-assembling capability of positively charged PA and formation of 1D nanofiber networks. The LbL technology is further used to fabricate supramolecular multilayered biomaterials by repeating the alternate deposition of both molecules. The fabrication process is monitored by quartz crystal microbalance, revealing that both materials can be successfully combined to conceive stable supramolecular systems. The morphological properties of the systems are studied by advanced microscopy techniques, revealing the nanostructured dimensions and 1D nanofibrous network of the assembly formed by the two molecules. Enhanced C2C12 cell adhesion, proliferation, and differentiation are observed on nanostructures having PA as outermost layer. Such supramolecular biomaterials demonstrate to be innovative matrices for cell culture and hold great potential to be used in the near future as promising biomimetic supramolecular nanoplatforms for practical applications.
publisher WILEY-V C H VERLAG GMBH
issn 1616-301X
isbn 1616-3028
year published 2017
volume 27
issue 17
digital object identifier (doi) 10.1002/adfm.201605122
web of science category Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter
subject category Chemistry; Science & Technology - Other Topics; Materials Science; Physics
unique article identifier WOS:000400449200001
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  impact metrics
journal impact factor (jcr 2016): 12.124
5 year journal impact factor (jcr 2016): 12.362
category normalized journal impact factor percentile (jcr 2016): 92.921
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