|
authors |
Martins, M; Azoia, NG; Melle-Franco, M; Ribeiro, A; Cavaco-Paulo, A |
|
nationality |
International |
|
journal |
ENGINEERING IN LIFE SCIENCES |
|
author keywords |
Cosmetics; Delivery; Dispersion; Fullerene C-60; Transdermal |
|
keywords |
IN-VITRO; PERCUTANEOUS-ABSORPTION; TRANSDERMAL PERMEATION; LIPID-PEROXIDATION; MOLECULAR-DYNAMICS; STRATUM-CORNEUM; SOLUBILITY; MODEL; PIG; NANOMATERIALS |
|
abstract |
Dispersions in transcutol/isopropylmyristate make C-60 fullerenemolecules suitable for transdermal delivery. We found that C-60 can successfully permeate the skin using pig skin in Franz diffusion cells. Molecular dynamics simulations and transmission electron microscopy confirmed these observations. Basic cosmetic formulations with transcutol/isopropylmyristate without harsh organic solvents show a high potential for delivery of C-60 for biopharmaceutical and cosmetics applications. |
|
publisher |
WILEY |
|
issn |
1618-0240 |
|
isbn |
1618-2863 |
|
year published |
2017 |
|
volume |
17 |
|
issue |
7 |
|
beginning page |
732 |
|
ending page |
738 |
|
digital object identifier (doi) |
10.1002/elsc.201600244 |
|
web of science category |
Biotechnology & Applied Microbiology |
|
subject category |
Biotechnology & Applied Microbiology |
|
unique article identifier |
WOS:000412288400003
|
