Engineering Membranes for Bone Regeneration
authors Caridade, SG; Mano, JF
nationality International
journal TISSUE ENGINEERING PART A
author keywords biomaterials; biomimetics; bone tissue engineering; bioactive composites; mineralization; membranes; films; osteoconduction; osteoinduction
keywords GUIDED TISSUE REGENERATION; POLYELECTROLYTE MULTILAYER FILMS; MESENCHYMAL STEM-CELLS; BIOACTIVE GLASS NANOPARTICLES; RESORBABLE POLYMERIC MEMBRANES; ENDOTHELIAL GROWTH-FACTOR; OSTEOBLAST-LIKE CELLS; HYDROXYAPATITE/COLLAGEN/PLGA COMPOSITE MEMBRANE; SEGMENTAL DIAPHYSEAL DEFECTS; PLASMA SURFACE MODIFICATION
abstract This review is focused on the use of membranes for the specific application of bone regeneration. The first section focuses on the relevance of membranes in this context and what are the specifications that they should possess to improve the regeneration of bone. Afterward, several techniques to engineer bone membranes by using bulk-like methods are discussed, where different parameters to induce bone formation are disclosed in a way to have desirable structural and functional properties. Subsequently, the production of nanostructured membranes using a bottom-up approach is discussed by highlighting the main advances in the field of bone regeneration. Primordial importance is given to the promotion of osteoconductive and osteoinductive capability during the membrane design. Whenever possible, the films prepared using different techniques are compared in terms of handability, bone guiding ability, osteoinductivity, adequate mechanical properties, or biodegradability. A last chapter contemplates membranes only composed by cells, disclosing their potential to regenerate bone.
publisher MARY ANN LIEBERT, INC
issn 1937-3341
year published 2017
volume 23
issue 23-24
beginning page 1502
ending page 1533
digital object identifier (doi) 10.1089/ten.tea.2017.0094
web of science category Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell Biology
subject category Cell Biology; Biotechnology & Applied Microbiology
unique article identifier WOS:000416479900001
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journal analysis (jcr 2019):
journal impact factor 3.496
5 year journal impact factor 3.428
category normalized journal impact factor percentile 55.601
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