Synthesis and bioactivity assessment of high silica content quaternary glasses with Ca: P ratios of 1.5 and 1.67, made by a rapid sol-gel process
authors Ben-Arfa, BAE; Fernandes, HR; Salvado, IMM; Ferreira, JMF; Pullar, RC
nationality International
journal JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
author keywords glass; glass-ceramics; crystallization; bioactivity; hydroxyapatite
keywords CALCIUM PYROPHOSPHATE BIOGLASSES; IN-VITRO; HYDROXYAPATITE; CRYSTALLIZATION; SPECTROSCOPY; SYSTEM; FLUIDS; ROUTE; IONS
abstract Sol-gel glasses in quaternary silica-sodium-calcium-phosphorous systems have been synthesized using a rotary evaporator for rapid drying without ageing. This novel fast drying method drastically decreases the total drying and ageing time from several weeks to only 1 hour, thus overcoming a serious drawback in sol-gel preparation procedures for bioglasses. This work investigates the bioactivity behavior of two glasses synthesized by this fast method, with Ca:P ratios of 1.5, and 1.67. X-ray diffraction (XRD), Inductive coupled plasma, Fourier-transform infrared, and Raman spectroscopy were used to confirm the bioactivity of the synthesized powders. MAS-NMR was also used to assess the degree of silica polymerization. The composition with a higher Ca:P=1.67 ratio showed better bioactivity in comparison to the one with Ca:P=1.5, which exhibited little bio-response with up to 4 weeks of immersion in SBF (simulated body fluid). It was also found that an orbital agitation rate of 120 rpm favors the interfacial bio-mineralization reactions, promoting the formation of a crystalline hydroxyapatite (HAp) layer at the surface of the (Ca:P=1.67) composition after 2 weeks immersion in SBF. (c) 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 510-520, 2018.
publisher WILEY
issn 1549-3296
year published 2018
volume 106
issue 2
beginning page 510
ending page 520
digital object identifier (doi) 10.1002/jbm.a.36239
web of science category Engineering, Biomedical; Materials Science, Biomaterials
subject category Engineering; Materials Science
unique article identifier WOS:000418830200021
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journal analysis (jcr 2017):
journal impact factor 3.231
5 year journal impact factor 3.329
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