Enhanced dissolution of ibuprofen using ionic liquids as catanionic hydrotropes
authors Sintra, TE; Shimizu, K; Ventura, SPM; Shimizu, S; Lopes, JNC; Coutinho, JAP
nationality International
journal PHYSICAL CHEMISTRY CHEMICAL PHYSICS
keywords ACTIVE PHARMACEUTICAL INGREDIENTS; ATOM FORCE-FIELD; AQUEOUS-SOLUTIONS; TEMPERATURE-DEPENDENCE; SODIUM-SALICYLATE; SOLUBILIZATION; NICOTINAMIDE; WATER; FORMS; DRUG
abstract The therapeutic effectiveness of a drug largely depends on its bioavailability, and thus ultimately on its aqueous solubility. Hydrotropes are compounds able to enhance the solubility of hydrophobic substances in aqueous media and therefore are extensively used in the formulation of drugs and personal care products. Recently, some ionic liquids were shown to display a strong ability to enhance the solubility of biomolecules through hydrotropy. In this work, the impact of the ionic liquid chemical structures and their concentration on the solubility of ibuprofen was evaluated and compared with the performance of conventional hydrotropes. The results obtained clearly evidence the exceptional capacity of ionic liquids to enhance the solubility of ibuprofen. [C(4)C(1)im][SCN] and [C(4)C(1)im][N(CN)(2)] seem to be the most promising ionic liquids for ibuprofen solubilisation, where an increase in the solubility of 60 -and 120-fold was observed with ionic liquid concentrations of circa 1 mol kg(-1), respectively. Dynamic light scattering and molecular dynamics simulations were used to investigate the mechanism of the IL-mediated drug solubility and the results obtained indicate that the structure of aqueous solutions of ionic liquids and the role it plays in the formation of ionic liquid-drug aggregates is the mechanism driving the hydrotropic dissolution.
publisher ROYAL SOC CHEMISTRY
issn 1463-9076
year published 2018
volume 20
issue 3
beginning page 2094
ending page 2103
digital object identifier (doi) 10.1039/c7cp07569c
web of science category Chemistry, Physical; Physics, Atomic, Molecular & Chemical
subject category Chemistry; Physics
unique article identifier WOS:000423019600077
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journal impact factor 3.906
5 year journal impact factor 4.224
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