Selective G-quadruplex binding by oligoarginine-Ru(dppz) metallopeptides
authors Bouzada, D; Salvado, I; Barka, G; Rama, G; Martinez-Costas, J; Lorca, R; Somoza, A; Melle-Franco, M; Vazquez, ME; Lopez, MV
nationality International
journal CHEMICAL COMMUNICATIONS
keywords METAL-COMPLEXES; DNA-BINDING; RUTHENIUM; INTERCALATORS; SPECTROSCOPY; LIGANDS; CELLS; DPPZ
abstract A set of Ru(II) metallopeptides containing the dppz ligand has been synthesized using SPPS methods. Fluorescence titration studies show that those metallopeptides featuring an octaarginine tail display a large binding preference for DNA G-quadruplex structures over those lacking it, and also that the interplay between the octoarginine functionalization and the ancillary ligand in the complex has an essential role in the recognition process. Furthermore, the oligoarginine metallopeptides are also efficiently internalized, causing cell death with signs of apoptosis.
publisher ROYAL SOC CHEMISTRY
issn 1359-7345
year published 2018
volume 54
issue 6
beginning page 658
ending page 661
digital object identifier (doi) 10.1039/c7cc08286j
web of science category Chemistry, Multidisciplinary
subject category Chemistry
unique article identifier WOS:000422861900020
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journal analysis (jcr 2017):
journal impact factor 6.290
5 year journal impact factor 6.064
category normalized journal impact factor percentile 83.918
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