Selective G-quadruplex binding by oligoarginine-Ru(dppz) metallopeptides

authors	Bouzada, D; Salvado, I; Barka, G; Rama, G; Martinez-Costas, J; Lorca, R; Somoza, A; Melle-Franco, M; Vazquez, ME; Lopez, MV
nationality	International
journal	CHEMICAL COMMUNICATIONS
keywords	METAL-COMPLEXES; DNA-BINDING; RUTHENIUM; INTERCALATORS; SPECTROSCOPY; LIGANDS; CELLS; DPPZ
abstract	A set of Ru(II) metallopeptides containing the dppz ligand has been synthesized using SPPS methods. Fluorescence titration studies show that those metallopeptides featuring an octaarginine tail display a large binding preference for DNA G-quadruplex structures over those lacking it, and also that the interplay between the octoarginine functionalization and the ancillary ligand in the complex has an essential role in the recognition process. Furthermore, the oligoarginine metallopeptides are also efficiently internalized, causing cell death with signs of apoptosis.
publisher	ROYAL SOC CHEMISTRY
issn	1359-7345
year published	2018
volume	54
issue	6
beginning page	658
ending page	661
digital object identifier (doi)	10.1039/c7cc08286j
web of science category	Chemistry, Multidisciplinary
subject category	Chemistry
unique article identifier	WOS:000422861900020