Enhanced extraction of phenolic compounds using choline chloride based deep eutectic solvents from Juglans regia L.
authors Vieira, V; Prieto, MA; Barros, L; Coutinho, JAP; Ferreira, ICFR; Ferreira, O
nationality International
journal INDUSTRIAL CROPS AND PRODUCTS
author keywords Phenolic compounds; Deep eutectic solvents; Heat-assisted extraction; Response surface methodology; Juglans regia L.
keywords RESPONSE-SURFACE METHODOLOGY; MICROWAVE-ASSISTED EXTRACTION; TEMPERATURE MIXTURES LTTMS; VIRGIN OLIVE OIL; IONIC LIQUIDS; OPTIMIZATION; ANTIOXIDANT; RECOVERY; DESIGN; FLAVONOIDS
abstract The extraction of phenolic compounds from walnut leaves (Juglans regia L.) was optimized using heat-assisted extraction and deep eutectic solvents based on choline chloride and carboxylic acids. A preliminary solvent screening was performed using a selected group of carboxylic acids as hydrogen bond donors, showing that the highest extraction yield of phenolic compounds was obtained using choline chloride mixtures with butyric or phenylpropionic acid at a mole ratio 1:2, with 20% of water (w/w). The extraction conditions (time, temperature and water proportion) were then optimized by an experimental design, assisted by response surface methodology. To evaluate the response, the three most abundant compounds identified by HPLC (neochlorogenic acid, quercetin 3-O-glucoside and quercetin O-pentoside) were quantified. Additionally, the solid/liquid ratio effect at the optimal conditions, in dose-response format, was studied in view of its upscale, not showing any significant decrease until 140 g/L. The results here presented provide valuable information towards the design of a process in a pre-industrial form for the extraction of phenolic compounds from J. regia leaves using deep eutectic solvents.
publisher ELSEVIER SCIENCE BV
issn 0926-6690
year published 2018
volume 115
beginning page 261
ending page 271
digital object identifier (doi) 10.1016/j.indcrop.2018.02.029
web of science category Agricultural Engineering; Agronomy
subject category Agriculture
unique article identifier WOS:000428824100031
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