Nanostructured Biopolymer/Few-Layer Graphene Freestanding Films with Enhanced Mechanical and Electrical Properties
authors Silva, C; Caridade, SG; Cunha, E; Sousa, MP; Rocha, H; Mano, JF; Paiva, MC; Alves, NM
nationality International
journal MACROMOLECULAR MATERIALS AND ENGINEERING
author keywords biomedical applications; freestanding multilayered films; functionalized graphene; natural polymers
keywords POLYELECTROLYTE MULTILAYER FILMS; FUNCTIONALIZED GRAPHENE; CROSS-LINKING; BIOMEDICAL APPLICATIONS; OXIDE NANOCOMPOSITES; POLY(METHYL METHACRYLATE); RAMAN-SPECTROSCOPY; GREEN FABRICATION; DRUG-DELIVERY; CHITOSAN
abstract In the present work, novel freestanding multilayered films based on chitosan (CHI), alginate (ALG), and functionalized few-layer graphene are developed through layer-by-layer assembly. First, functionalized few-layer graphene aqueous suspensions are prepared from graphite by a stabilizer-assisted liquid phase exfoliation process, using a pyrene derivative as stabilizer. Afterward, the films are produced and their physical, morphological, thermal, and mechanical properties are evaluated. Furthermore, their degradation and swelling profiles, as well as their biological behavior, are assessed. The incorporation of functionalized few-layer graphene results in films with a nanolayered structure, lower roughness than the control CHI/ALG films, and hydrophilic behavior. The mechanical characterization reveals an increase of the Young's modulus, ultimate tensile strength, and elongation at break due to the incorporation of the graphene derivative. A decrease in the electrical resistivity of the multilayered films is also observed. The biological assays reveal improved cytocompatibility toward L929 cells when functionalized few-layer graphene is incorporated in the CHI/ALG matrix. Therefore, these new graphene-reinforced multilayered films exhibit interesting properties and great potential for biomedical applications, particularly in wound healing and cardiac and bone tissue engineering.
publisher WILEY-V C H VERLAG GMBH
issn 1438-7492
year published 2018
volume 303
issue 4
digital object identifier (doi) 10.1002/mame.201700316
web of science category Materials Science, Multidisciplinary; Polymer Science
subject category Materials Science; Polymer Science
unique article identifier WOS:000430542900001
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  impact metrics
journal analysis (jcr 2019):
journal impact factor 3.853
5 year journal impact factor 3.368
category normalized journal impact factor percentile 76.488
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