An Integrated Multifunctional Nanoplatform for Deep-Tissue Dual-Mode Imaging
authors Yang, F; Skripka, A; Benayas, A; Dong, XK; Hong, SH; Ren, FQ; Oh, JK; Liu, XY; Vetrone, F; Ma, DL
nationality International
journal ADVANCED FUNCTIONAL MATERIALS
author keywords deep-tissue optical imaging; dual-mode imaging; magnetic resonance imaging; multifunctional nanoparticles; near-infrared to near-infrared
keywords 2ND BIOLOGICAL WINDOW; UP-CONVERSION LUMINESCENT; IN-VIVO; PHOTOTHERMAL THERAPY; NANOPARTICLE PROBES; MAGNETIC-RESONANCE; DRUG-DELIVERY; QUANTUM DOTS; FLUORESCENCE; NANOCRYSTALS
abstract The combination of biocompatible superparamagnetic and photoluminescent nanoparticles (NPs) is intensively studied as highly promising multifunctional (magnetic confinement and targeting, imaging, etc.) tools in biomedical applications. However, most of these hybrid NPs exhibit low signal contrast and shallow tissue penetration for optical imaging due to tissue-induced optical extinction and autofluorescence, since in many cases, their photoluminescent components emit in the visible spectral range. Yet, the search for multifunctional NPs suitable for high photoluminescence signal-to-noise ratio, deep-tissue imaging is still ongoing. Herein, a biocompatible core/shell/shell sandwich structured Fe3O4@SiO2@NaYF4:Nd3+ nanoplatform possessing excellent superparamagnetic and near-infrared (excitation) to near-infrared (emission), i.e., NIR-to-NIR photoluminescence properties is developed. They can be rapidly magnetically confined, allowing the NIR photoluminescence signal to be detected through a tissue as thick as 13 mm, accompanied by high T-2 relaxivity in magnetic resonance imaging. The fact that both the excitation and emission wavelengths of these NPs are in the optically transparent biological windows, along with excellent photostability, fast magnetic response, significant T-2-contrast enhancement, and negligible cytotoxicity, makes them extremely promising for use in high-resolution, deep-tissue dual-mode (optical and magnetic resonance) in vivo imaging and magnetic-driven applications.
publisher WILEY-V C H VERLAG GMBH
issn 1616-301X
year published 2018
volume 28
issue 11
digital object identifier (doi) 10.1002/adfm.201706235
web of science category Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter
subject category Chemistry; Science & Technology - Other Topics; Materials Science; Physics
unique article identifier WOS:000427110100026
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journal analysis (jcr 2017):
journal impact factor 13.325
5 year journal impact factor 13.274
category normalized journal impact factor percentile 94.154
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