Lipophilic composition of Scabiosa stellata L.: an underexploited plant from Batna (Algeria)

authors	Rahmouni, N; Pinto, DCGA; Santos, SAO; Beghidja, N; Silva, AMS
nationality	International
journal	CHEMICAL PAPERS
author keywords	Scabiosa stellata L.; GC-MS profile; Fatty acids; Sterols; Terpenes; Nutritional indexes
keywords	URSOLIC ACID; PHYTOSTEROLS; TRIMETHYLSILYL; FRAGMENTATION; CONSTITUENTS; ANTIOXIDANT; EXTRACTIVES; DISEASE; OIL
abstract	Scabiosa stellata L. is the less-studied plant of the species belonging to the genus Scabiosa, but the fact that several Scabiosa species are used in traditional medicine is an incentive to study this species. The profile of the S. stellata hexane extract was established by gas chromatography-mass spectrometry and allowed to conclude that fatty acids and their derivatives (87%) are the major chemical families of this extract. From the identified components, linoleic (19%), palmitic (20%) and linolenic (34%) acids are the major ones. Additionally, triterpenoids, namely beta-sitosterol, stigmasterol, oleanolic and ursolic acids were also found. Simultaneously, the phytochemical study of this extract allowed the isolation and full characterization using 1D and 2D NMR experiments (H-1 and C-13 NMR, HSQC, COSY, HMBC) of interesting metabolites such as 1,3-O-dilinoleoyl-2-O-palmitoyl glycerol and 1-O-linolenoyl-2-O-linoleoyl-3-O-oleoyl glycerol. This first assessment of S. stellata less polar constituents allowed the identification of several important compounds among which, ursolic and stearic acids, 1,3-O-dilinoleoyl-2-O-palmitoyl glycerol and 1-O-linolenoyl-2-O-linoleoyl-3-O-oleoyl glycerol, were found, for the first time in Scabiosa genus. The results reported, index of atherogenicity (AI = 0.55), index of thrombogenicity (TI = 0.23) and the fatty acid ratio (omega-6/omega-3 = 0.55), point out the nutritional value of S. stellata. [GRAPHICS] .
publisher	SPRINGER INTERNATIONAL PUBLISHING AG
issn	2585-7290
year published	2018
volume	72
issue	3
beginning page	753
ending page	762
digital object identifier (doi)	10.1007/s11696-017-0308-3
web of science category	Chemistry, Multidisciplinary
subject category	Chemistry
unique article identifier	WOS:000425783100024