Porphyrins and Phthalocyanines Decorated with Dendrimers: Synthesis and Biomedical Applications
authors Figueira, F; Pereira, PMR; Silva, S; Cavaleiro, JAS; Tome, JPC
nationality International
journal CURRENT ORGANIC SYNTHESIS
author keywords Dendrimers; porphyrin; phthalocyanine; photomedicine; photodynamic therapy; photodiagnostic
keywords POLYION COMPLEX MICELLES; DENDRITIC POLYGLUTAMIC PORPHYRINS; OLIGO(ETHYLENEOXY) SURFACE GROUPS; ARYL ETHER DENDRIMERS; PHOTODYNAMIC THERAPY; PHOTOPHYSICAL PROPERTIES; POLYMERIC MICELLES; DRUG-DELIVERY; GLYCODENDRIMERIC PHENYLPORPHYRINS; SUPRAMOLECULAR NANOCARRIERS
abstract In medical applications such as drug delivery, gene transfection and imaging the formation of systems with well-defined sizes and shapes are of significant interest. For this reason the design of dendrimers with modulated size, shape, branching length/density, and their surface functionality, clearly distinguishes these structures as unique and optimum carriers for medical applications. The bioactive agents may be encapsulated into the interior of the dendrimers or chemically attached/physically adsorbed onto the dendrimer surface, with the option of tailoring the carrier to the specific needs of the active material and its therapeutic applications. In this regard one area with growing attention is photodynamic therapy (PDT) where a photosensitizer combined with light and molecular oxygen can easily cause irreversible damage to the target tissue. Nevertheless most of the photosensitizers have solubility issues when attempts are made to dissolve them in aqueous environments, hampering in most cases their medical applicability. Currently, investigations are running towards the combination of these photosensitizers with dendrimers increasing their organization, solubility and specificity to the target tissues. In this communication we review the latest advancements in the synthesis of porphyrin and phthalocyanine dendrimer architectures, regarding their utility as biomedical agents.
publisher BENTHAM SCIENCE PUBL LTD
issn 1570-1794
year published 2014
volume 11
issue 1
beginning page 110
ending page 126
digital object identifier (doi) 10.2174/15701794113106660089
web of science category Chemistry, Organic
subject category Chemistry
unique article identifier WOS:000334762800008
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  impact metrics
journal analysis (jcr 2017):
journal impact factor 1.690
5 year journal impact factor 1.776
category normalized journal impact factor percentile 39.474
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