Bioinspired bone therapies using naringin: applications and advances
authors Lavrador, P; Gaspar, VM; Mano, JF
nationality International
journal DRUG DISCOVERY TODAY
keywords NF-KAPPA-B; CONTROLLED-RELEASE STRATEGIES; POSTMENOPAUSAL OSTEOPOROSIS; OSTEOBLAST DIFFERENTIATION; RHEUMATOID-ARTHRITIS; OVARIECTOMIZED RATS; SIGNALING PATHWAY; NATURAL-PRODUCTS; STEM-CELLS; MECHANISMS
abstract The use of natural compounds for treating chronic bone diseases holds remarkable potential. Among these therapeutics, naringin, a flavanone glycoside, represents one of the most promising candidates owing to its multifaceted effect on bone tissues. This review provides an up-to-date overview on naringin applications in the treatment of bone disorders, such as osteoporosis and osteoarthritis, and further highlights its potential for stem cell pro-osteogenic differentiation therapies. A critical perspective on naringin clinical translation is also provided. The topic is discussed in light of recently developed biomaterial-based approaches that potentiate its bioavailability and bioactivity. Overall, the reported pro-osteogenic, antiresorptive and antiadipogenic properties establish this flavanone as an exciting candidate for application in bone tissue engineering and regenerative medicine.
publisher ELSEVIER SCI LTD
issn 1359-6446
year published 2018
volume 23
issue 6
beginning page 1293
ending page 1304
digital object identifier (doi) 10.1016/j.drudis.2018.05.012
web of science category Pharmacology & Pharmacy
subject category Pharmacology & Pharmacy
unique article identifier WOS:000437071200015
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journal analysis (jcr 2017):
journal impact factor 6.848
5 year journal impact factor 6.536
category normalized journal impact factor percentile 95.977
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