Bioinspired bone therapies using naringin: applications and advances

authors	Lavrador, P; Gaspar, VM; Mano, JF
nationality	International
journal	DRUG DISCOVERY TODAY
keywords	NF-KAPPA-B; CONTROLLED-RELEASE STRATEGIES; POSTMENOPAUSAL OSTEOPOROSIS; OSTEOBLAST DIFFERENTIATION; RHEUMATOID-ARTHRITIS; OVARIECTOMIZED RATS; SIGNALING PATHWAY; NATURAL-PRODUCTS; STEM-CELLS; MECHANISMS
abstract	The use of natural compounds for treating chronic bone diseases holds remarkable potential. Among these therapeutics, naringin, a flavanone glycoside, represents one of the most promising candidates owing to its multifaceted effect on bone tissues. This review provides an up-to-date overview on naringin applications in the treatment of bone disorders, such as osteoporosis and osteoarthritis, and further highlights its potential for stem cell pro-osteogenic differentiation therapies. A critical perspective on naringin clinical translation is also provided. The topic is discussed in light of recently developed biomaterial-based approaches that potentiate its bioavailability and bioactivity. Overall, the reported pro-osteogenic, antiresorptive and antiadipogenic properties establish this flavanone as an exciting candidate for application in bone tissue engineering and regenerative medicine.
publisher	ELSEVIER SCI LTD
issn	1359-6446
year published	2018
volume	23
issue	6
beginning page	1293
ending page	1304
digital object identifier (doi)	10.1016/j.drudis.2018.05.012
web of science category	Pharmacology & Pharmacy
subject category	Pharmacology & Pharmacy
unique article identifier	WOS:000437071200015