Biocompatible hybrids based on nanographene oxide covalently linked to glycolporphyrins: Synthesis, characterization and biological evaluation
authors Santos, CIM; Goncalves, G; Cicuendez, M; Mariz, I; Silva, VS; Oliveira, H; Campos, F; Vieira, SI; Marques, PAAP; Macoas, EMS; Neves, MGPMS; Martinho, JMG
nationality International
journal CARBON
keywords NANO-GRAPHENE OXIDE; NONLINEAR-OPTICAL PROPERTIES; PHOTODYNAMIC THERAPY; PHOTOTHERMAL THERAPY; PORPHYRIN; CANCER; FUNCTIONALIZATION; NANOPARTICLES; POLYMERS; CELLS
abstract The major limitation in the development of hybrids based on graphene oxide (GO) and porphyrins is their dispersibility and stability in aqueous systems due to the hydrophobic character induced by porphyrins. Most of the previous approaches reported the direct functionalization of GO with polyethylene glycol (PEG) chains followed by the self-assembly of porphyrins by pi-pi interactions. Here, new hybrids were prepared using porphyrins previously functionalized with different number/types of glycol branches to be covalently attached through esterification to the carboxyl groups of GO sheets of nano-metric dimensions. The number of the glycol chains and its relative position in the porphyrin core showed to be fundamental to improve the hybrids dispersion and stability in aqueous solutions. The best performing hybrids were characterized by transmission electron microscopy, X-ray photoelectron spectroscopy, Fourier transform infrared, UV-Vis absorption and fluorescence spectroscopy. The in vitro biocompatibility assessment of these hybrids was conducted using human Saos-2 cells. Their effects on cell proliferation and viability, the generation of reactive oxygen species as well as the cell morphology after cell uptake were analysed. The results demonstrate the biocompatibility of these hybrid nano-materials with human Saos-2 cells, which is very promising for future application in biomedicine namely in cancer therapy. (C) 2018 Elsevier Ltd. All rights reserved.
publisher PERGAMON-ELSEVIER SCIENCE LTD
issn 0008-6223
year published 2018
volume 135
beginning page 202
ending page 214
digital object identifier (doi) 10.1016/j.carbon.2018.04.040
web of science category Chemistry, Physical; Materials Science, Multidisciplinary
subject category Chemistry; Materials Science
unique article identifier WOS:000436800100023
  ciceco authors
  impact metrics
journal analysis (jcr 2017):
journal impact factor 7.082
5 year journal impact factor 7.088
category normalized journal impact factor percentile 86.140
dimensions (citation analysis):
altmetrics (social interaction):



 


Sponsors

1suponsers_list_ciceco.jpg