authors |
Pereira, RFP; Zehbe, K; Gunter, C; dos Santos, T; Nunes, SC; Paz, FAA; Silva, MM; Granja, PL; Taubert, A; Bermudez, VD |
nationality |
International |
journal |
ACS OMEGA |
keywords |
BOMBYX-MORI SILK; SHIFT CONTOUR PLOTS; I STRUCTURE; BIOMATERIAL SCAFFOLDS; CHIMERIC PROTEINS; BIOACTIVE GLASSES; SILICA FIBERS; FILMS; NMR; COMPOSITES |
abstract |
New mesoporous silk fibroin (SF)/silica hybrids were processed via a one-pot soft and energy-efficient sol-gel chemistry and self-assembly from a silica precursor, an acidic or basic catalyst, and the ionic liquid 1-butyl-3-methylimidazolium chloride, acting as both solvent and mesoporosity-inducer. The as-prepared materials were obtained as slightly transparent-opaque, amorphous monoliths, easily transformed into powders, and stable up to ca. 300 degrees C. Structural data suggest the formation of a hexagonal mesostructure with low range order and apparent surface areas, pore volumes, and pore radii of 205-263 m(2) g(-1), 0.16-0.19 cm(3) g(-1), and 1.2-1.6 nm, respectively. In all samples, the dominating conformation of the SF chains is the beta-sheet. Cytotoxicity/bioactivity resazurin assays and fluorescence microscopy demonstrate the high viability of MC3T3 pre-osteoblasts to indirect (>= 99 +/- 9%) and direct (78 +/- 2 to 99 +/- 13%) contact with the SF/silica materials. Considering their properties and further improvements, these systems are promising candidates to be explored in bone tissue engineering. They also offer excellent prospects as electrolytes for solid-state electrochemical devices, in particular for fuel cells. |
publisher |
AMER CHEMICAL SOC |
issn |
2470-1343 |
year published |
2018 |
volume |
3 |
issue |
9 |
beginning page |
10811 |
ending page |
10822 |
digital object identifier (doi) |
10.1021/acsomega.8b02051 |
web of science category |
Chemistry, Multidisciplinary |
subject category |
Chemistry |
unique article identifier |
WOS:000446186000039
|
ciceco authors
impact metrics
journal analysis (jcr 2019):
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journal impact factor |
2.87 |
5 year journal impact factor |
2.905 |
category normalized journal impact factor percentile |
54.52 |
dimensions (citation analysis):
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altmetrics (social interaction):
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