Nanocellulose-based antifungal nanocomposites against the polymorphic fungus Candida albicans
authors Vilela, C; Oliveira, H; Almeida, A; Silvestre, AJD; Freire, CSR
nationality International
journal CARBOHYDRATE POLYMERS
author keywords Antifungal activity; Bacterial nanocellulose; Candida albicans; Cutaneous treatment; In-situpolymerization; Poly([2-(methacryloyloxy) ethyl] trimethylammonium chloride)
keywords BACTERIAL CELLULOSE; ANTIMICROBIAL ACTIVITY; POLY(IONIC LIQUID)S; REMOVAL PROPERTIES; NATURAL-PRODUCTS; CHLORIDE; PATHOGENICITY; COMPOSITES; COPOLYMERS; RADIATION
abstract The design of functional materials capable of fighting fungal infections is of paramount importance given the intricate problem of multidrug-resistant pathogenic fungi. Herein, nanocomposites consisting of cross-linked poly([2-(methacryloyloxy) ethyl] trimethylammonium chloride) (PMETAC) and bacterial nanocellulose (BNC) were prepared, characterized and tested towards the polymorphic fungus Candida albicans. The BNC three-dimensional network enabled the in-situ polymerization of the non-toxic and bioactive quaternary-ammonium monomer, which originated transparent nanocomposites containing 10 and 40 wt.% of cross-linked PMETAC. Furthermore, the nanocomposites exhibit UV-A and UV-B blocking properties, high water-uptake capacity, thermal stability up to 200 degrees C, good viscoelastic (storage modulus > 1.7 GPa) and mechanical (Young's modulus >= 2.4 GPa) properties and are non-cytotoxic to human keratinocytes (HaCaT cells). The fungal inactivation reached a 4.4 +/- 0.14-log CFU reduction for the nanocomposite containing only 10 wt.% of cross-linked PMETAC. Hence, these bioactive and non-cytotoxic materials can constitute potentially effective systems for the treatment of C. albicans infections.
publisher ELSEVIER SCI LTD
issn 0144-8617
year published 2019
volume 217
beginning page 207
ending page 216
digital object identifier (doi) 10.1016/j.carbpol.2019.04.046
web of science category Chemistry, Applied; Chemistry, Organic; Polymer Science
subject category Chemistry; Polymer Science
unique article identifier WOS:000467373800023
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journal analysis (jcr 2017):
journal impact factor 5.158
5 year journal impact factor 5.326
category normalized journal impact factor percentile 93.599
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