authors |
Cicuendez, M; Silva, VS; Santos, J; Coimbra, A; Oliveira, H; Ayan-Varela, M; Paredes, JI; Villar-Rodil, S; Vila, M |
nationality |
International |
journal |
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS |
author keywords |
Transition metal dichalcogenides (TMDCs); MoS2; Biodispersants; Biocompatibility; in vitro cell response; Osteoblast |
keywords |
MOLYBDENUM-DISULFIDE; AQUEOUS DISPERSIONS; GRAPHENE ANALOGS; DRUG-DELIVERY; NANOSHEETS; EXFOLIATION; DICHALCOGENIDES; NANOPARTICLES; NANOMATERIALS; CULTURE |
abstract |
Two-dimensional transition metal dichalcogenides (TMDCs), such as MoS2 and WS2, have recently emerged as nanomaterials with potential use in biomedicine. An attractive means to favor their interaction with biological media is the use of proper biomolecules as exfoliating/dispersing agents. Here, MoS2 flakes were stabilized with different small functional biomolecules such as adenosine monophosphate (AMP), guanosine monophosphate (GMP) and flavin mononucleotide (FMN) through the strong nucleotide - MoS2 interaction of Lewis acid-base type, rather than just on the weak dispersive and hydrophobic forces commonly associated with the use of many surfactants. The impact of the nucleotide-stabilized MoS2 flakes on the viability and cell proliferation, on the production of intracellular reactive oxygen species (ROS), and on the preosteoblast differentiation process (early stage) has been also evaluated, as well as the incorporation and intracellular localization of the nanomaterials by MC3T3-E1 and Saos-2 cells. The nucleotide-stabilized MoS2 flakes were found to exhibit excellent biocompatibility. Furthermore, their incorporation did not affect the integrity of the cell plasma membrane, which makes them ideal candidates for delivering drug/gene directly into cells. The in vitro cell response of tumor cells to these nanomaterials differs from that of undifferentiated cells, which provides the basis for their potential use in cancer therapy. |
publisher |
ELSEVIER SCIENCE BV |
issn |
0928-4931 |
isbn |
1873-0191 |
year published |
2019 |
volume |
100 |
beginning page |
11 |
ending page |
22 |
digital object identifier (doi) |
10.1016/j.msec.2019.02.002 |
web of science category |
Materials Science, Biomaterials |
subject category |
Materials Science |
unique article identifier |
WOS:000466059700002
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ciceco authors
impact metrics
journal analysis (jcr 2019):
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journal impact factor |
5.88 |
5 year journal impact factor |
5.364 |
category normalized journal impact factor percentile |
82.895 |
dimensions (citation analysis):
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altmetrics (social interaction):
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