Antibacterial efficiency of alkali-free bio-glasses incorporating ZnO and/or SrO as therapeutic agents
authors Popa, AC; Fernandes, HR; Necsulescu, M; Luculescu, C; Cioangher, M; Dumitru, V; Stuart, BW; Grant, DM; Ferreira, JMF; Stan, GE
nationality International
journal CERAMICS INTERNATIONAL
author keywords Bioactive glass; Doping; CTE; Antibacterial activity; Cytocompatibility
keywords SIMULATED BODY-FLUID; BIOACTIVE GLASS; THERMAL-EXPANSION; ANTIMICROBIAL ACTIVITY; ESCHERICHIA-COLI; CHEMICAL-COMPOSITION; HYDROGEN-PEROXIDE; SILICATE-GLASSES; IMMUNE-RESPONSE; STRONTIUM
abstract A series of seven alkali-free silica-based bioactive glasses (SBG) with ZnO and/or SrO additives (in concentrations of 0-12 mol%) were synthesized by melt-quenching, aiming to delineate a candidate formulation possessing (i) a coefficient of thermal expansion (CTE) similar to the one of titanium (Ti) and its medical grade super alloys (crucial for the future development of mechanically adherent implant-type SBG coatings) and (ii) antibacterial efficiency, while (iii) conserving a good cytocompatibility. The SBGs powders were multi-parametrically evaluated by X-ray diffraction, Fourier transform infrared and micro-Raman spectroscopy, dilatometry, inductively coupled plasma mass spectrometry, antibacterial (against Staphylococcus aureus and Escherichia coli strains) suspension inhibition and agar diffusion tests, and human mesenchymal stem cells cytocompatibility assays. The results showed that the coupled incorporation of zinc and strontium ions into the parent glass composition has a combinatorial and additive benefit. In particular, the "Z6S4" formulation (mol%: SiO2-38.49, CaO-32.07, P2O5-5.61, MgO-13.24, CaF2-0.59, ZnO-6.0, SrO-4.0) conferred strong antimicrobial activity against both types of strains, minimal cytotoxicity combined with good stem cells viability and proliferation, and a CTE (similar to 8.7 x 10(-6) x degrees C-1) matching well those of the Ti-based implant materials.
publisher ELSEVIER SCI LTD
issn 0272-8842
year published 2019
volume 45
issue 4
beginning page 4368
ending page 4380
digital object identifier (doi) 10.1016/j.ceramint.2018.11.112
web of science category Materials Science, Ceramics
subject category Materials Science
unique article identifier WOS:000458228200027
  ciceco authors
  impact metrics
journal analysis (jcr 2017):
journal impact factor 3.057
5 year journal impact factor 2.882
category normalized journal impact factor percentile 94.444
dimensions (citation analysis):
altmetrics (social interaction):



 


Sponsors

1suponsers_list_ciceco.jpg