Development of novel Cu(I) compounds with vitamin B-1 derivative and their potential application as anticancer drugs

authors	Brandao, P; Guieu, S; Correia-Branco, A; Silva, C; Martel, F
nationality	International
journal	INORGANICA CHIMICA ACTA
author keywords	Copper(I); Vitamin B-1 derivatives; Thiochrome; Caco-2 cells
keywords	COPPER-COMPLEXES SYNTHESIS; METAL-ION INTERACTIONS; CRYSTAL-STRUCTURE; IN-VITRO; STRUCTURAL-CHARACTERIZATION; CYTOTOXIC PROPERTIES; MOLECULAR-STRUCTURE; ANTITUMOR-ACTIVITY; 2 SALTS; THIAMINE
abstract	The synthesis and crystal structure of two new copper(I) compounds with molecular formula of {Cu-4[(mu(3)-thiocrome)(2)Cl-4]center dot 2(H2O)}(n) 1, and Cu-2[(mu(2)-thiocrome)(2)Cl-2] 2 are reported. The crystal structure of compounds 1 and 2 are solved by single crystal X-ray diffraction. The reaction of Cu(II) with thiamine chloride in water at room temperature produces Cu(I) thiochrome compounds 1 and 2. Compound 1 shows a 1D chain structure based on the linkage of two crystallographic different copper centers and thiochrome ligand through the N(1), N (2) and N(3) nitrogen atoms. Compound 2 is a 0D dimeric copper structure assembled by two thiochrome ligands. For both compounds, the copper(I) centers exhibits a distorted trigonal pyramidal geometry. The antitumor capacity of both compounds was tested in vitro against a human cancer cell line, the colorectal adenocarcinoma (Caco-2) cell line, by determining their effect on cell viability. The two compounds showed similar IC50 values, and were slightly more potent than cisplatin, against the same cell line.
publisher	ELSEVIER SCIENCE SA
issn	0020-1693
isbn	1873-3255
year published	2019
volume	487
beginning page	287
ending page	294
digital object identifier (doi)	10.1016/j.ica.2018.12.017
web of science category	Chemistry, Inorganic & Nuclear
subject category	Chemistry
unique article identifier	WOS:000456799100038