Solvatochromism as a new tool to distinguish structurally similar compounds
authors Madeira, PP; Loureiro, JA; Freire, MG; Coutinho, JAP
nationality International
journal JOURNAL OF MOLECULAR LIQUIDS
author keywords Solvatochromic method; Structurally similar compounds; Biosimilars; Quality control; Biomedical diagnosis
keywords ELECTRONIC-SPECTRA; SOLVENT PROPERTIES; GLYCOSYLATION; PROTEINS; SCALE; WATER; BETA
abstract It is here reported a new concept based on solvatochromism to distinguish structurally similar compounds in aqueous solutions by the analysis of the stabilization of electronic excited states. The sensitivity of this approach to differentiate similar organic compounds, such as structural isomers or compound differing in the number of methylene groups, or proteins with conformational changes induced by being or not bound to cofactors, differing in two amino acids substitutions, or differing in their glycosylation profile, is demonstrated. The sensitivity of the proposed approach, based on the solvatochromic method, opens the path to its use as an auxiliary analytical tool in biomedical diagnosis/prognosis or in quality control of biologic-based drugs. (C) 2018 Elsevier B.V. All rights reserved.
publisher ELSEVIER SCIENCE BV
issn 0167-7322
year published 2019
volume 274
beginning page 740
ending page 745
digital object identifier (doi) 10.1016/j.molliq.2018.11.050
web of science category Chemistry, Physical; Physics, Atomic, Molecular & Chemical
subject category Chemistry; Physics
unique article identifier WOS:000457660000082
  ciceco authors
  impact metrics
journal analysis (jcr 2017):
journal impact factor 4.513
5 year journal impact factor 3.929
category normalized journal impact factor percentile 80.153
dimensions (citation analysis):
altmetrics (social interaction):



 


Sponsors

1suponsers_list_ciceco.jpg