Multifunctional Self-Assembled Supernanoparticles for Deep-Tissue Bimodal Imaging and Amplified Dual-Mode Heating Treatment

authors	Yang, F; Skripka, A; Tabatabaei, MS; Hong, SH; Ren, FQ; Benayas, A; Oh, JK; Martel, S; Liu, XY; Vetrone, F; Ma, DL
nationality	International
journal	ACS NANO
author keywords	self-assembly; multifunctional supernanoparticles; second biological window; bimodal imaging; dual-modal heating
keywords	IRON-OXIDE NANOPARTICLES; PBS QUANTUM DOTS; MAGNETIC-RESONANCE; PHOTOTHERMAL THERAPY; HIGH-PERFORMANCE; CANCER-THERAPY; SIZE; NANOCRYSTALS; HYPERTHERMIA; EFFICIENCY
abstract	Developing multifunctional therapeutic and diagnostic (theranostic) nanoplatforms is critical for addressing challenging issues associated with cancers. Here, self-assembled supernanoparticles consisting of superparamagnetic Fe3O4 nanoparticles and photo luminescent PbS/CdS quantum dots whose emission lies within the second biological window (II-BW) are developed. The proposed self assembled Fe3O4 and PbS/CdS (II-BW) supernanoparticles [SASNs (II-BW)] exhibit outstanding photoluminescence detectable through a tissue as thick as 14 mm, by overcoming severe light extinction and concomitant autofluorescence in II-BW, and significantly enhanced T-2 relaxivity (282 mM(-1) s(-1), ca. 4 times higher than free Fe3O4 nanoparticles) due to largely enhanced magnetic field inhomogeneity. On the other hand, SASNs (II-BW) possess the dual capacity to act as both magnetothermal and photothermal agents, overcoming the main drawbacks of each type of heating separately. When SASNs (II-BW) are exposed to the dual-mode (magnetothermal and photothermal) heating, the thermal energy transfer efficiency is amplified 7-fold compared with magnetic heating alone. These results, in hand with the excellent photo- and colloidal stability, and negligible cytotoxicity, demonstrate the potential use of SASNs (II-BW) for deep-tissue bimodal (magnetic resonance and photoluminescence) in vivo imaging, while simultaneously providing the possibility of SASNs (II-BW)-mediated amplified dual-mode heating treatment for cancer therapy.
publisher	AMER CHEMICAL SOC
issn	1936-0851
isbn	1936-086X
year published	2019
volume	13
issue	1
beginning page	408
ending page	420
digital object identifier (doi)	10.1021/acsnano.8b06563
web of science category	Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary
subject category	Chemistry; Science & Technology - Other Topics; Materials Science
unique article identifier	WOS:000456749900040