Multifunctional Self-Assembled Supernanoparticles for Deep-Tissue Bimodal Imaging and Amplified Dual-Mode Heating Treatment
authors Yang, F; Skripka, A; Tabatabaei, MS; Hong, SH; Ren, FQ; Benayas, A; Oh, JK; Martel, S; Liu, XY; Vetrone, F; Ma, DL
nationality International
journal ACS NANO
author keywords self-assembly; multifunctional supernanoparticles; second biological window; bimodal imaging; dual-modal heating
keywords IRON-OXIDE NANOPARTICLES; PBS QUANTUM DOTS; MAGNETIC-RESONANCE; PHOTOTHERMAL THERAPY; HIGH-PERFORMANCE; CANCER-THERAPY; SIZE; NANOCRYSTALS; HYPERTHERMIA; EFFICIENCY
abstract Developing multifunctional therapeutic and diagnostic (theranostic) nanoplatforms is critical for addressing challenging issues associated with cancers. Here, self-assembled supernanoparticles consisting of superparamagnetic Fe3O4 nanoparticles and photo luminescent PbS/CdS quantum dots whose emission lies within the second biological window (II-BW) are developed. The proposed self assembled Fe3O4 and PbS/CdS (II-BW) supernanoparticles [SASNs (II-BW)] exhibit outstanding photoluminescence detectable through a tissue as thick as 14 mm, by overcoming severe light extinction and concomitant autofluorescence in II-BW, and significantly enhanced T-2 relaxivity (282 mM(-1) s(-1), ca. 4 times higher than free Fe3O4 nanoparticles) due to largely enhanced magnetic field inhomogeneity. On the other hand, SASNs (II-BW) possess the dual capacity to act as both magnetothermal and photothermal agents, overcoming the main drawbacks of each type of heating separately. When SASNs (II-BW) are exposed to the dual-mode (magnetothermal and photothermal) heating, the thermal energy transfer efficiency is amplified 7-fold compared with magnetic heating alone. These results, in hand with the excellent photo- and colloidal stability, and negligible cytotoxicity, demonstrate the potential use of SASNs (II-BW) for deep-tissue bimodal (magnetic resonance and photoluminescence) in vivo imaging, while simultaneously providing the possibility of SASNs (II-BW)-mediated amplified dual-mode heating treatment for cancer therapy.
publisher AMER CHEMICAL SOC
issn 1936-0851
year published 2019
volume 13
issue 1
beginning page 408
ending page 420
digital object identifier (doi) 10.1021/acsnano.8b06563
web of science category Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary
subject category Chemistry; Science & Technology - Other Topics; Materials Science
unique article identifier WOS:000456749900040
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journal analysis (jcr 2017):
journal impact factor 13.709
5 year journal impact factor 14.820
category normalized journal impact factor percentile 95.274
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