A compendium of current developments on polysaccharide and protein-based microneedles
authors Fonseca, DFS; Vilela, C; Silvestre, AJD; Freire, CSR
nationality International
journal INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
author keywords Microneedles; Biopolymers; Polysaccharides; Proteins; Transdermal application
keywords TRANSDERMAL DRUG-DELIVERY; SILK FIBROIN MICRONEEDLES; BIODEGRADABLE POLYMER MICRONEEDLES; 2-LAYERED DISSOLVING MICRONEEDLES; HYALURONIC-ACID; CHITOSAN MICRONEEDLES; SKIN PENETRATION; MOLECULAR-WEIGHT; TRANSCUTANEOUS IMMUNIZATION; BIOMEDICAL APPLICATIONS
abstract Microneedles (MNs), i.e. minimally invasive three-dimensional microstructures that penetrate the stratum corneum inducing relatively little or no pain, have been studied as appealing therapeutic vehicles for transdermal drug delivery. Over the last years, the fabrication of MNs using biopolymers, such as polysaccharides and proteins, has sparked the imagination of scientists due to their recognized biocompatibility, biodegradability, ease of fabrication and sustainable character. Owing to their wide range of functional groups, polysaccharides and proteins enable the design and preparation of materials with tunable properties and functionalities. Therefore, these biopolymer-based MNs take a revolutionary step offering great potential not only in drug administration, but also in sensing and response to physiological stimuli. In this review, a critical and comprehensive overview of the polysaccharides and proteins employed in the design and engineering of MNs will be given. The strategies adopted for their preparation, their advantages and disadvantages will be also detailed. In addition, the potential and challenges of using these matrices to deliver drugs, vaccines and other molecules will be discussed. Finally, this appraisal ends with a perspective on the possibilities and challenges in research and development of polysaccharide and protein MNs, envisioning the future advances and clinical translation of these platforms as the next generation of drug delivery systems. (C) 2019 Elsevier B.V. All rights reserved.
publisher ELSEVIER
issn 0141-8130
year published 2019
volume 136
beginning page 704
ending page 728
digital object identifier (doi) 10.1016/j.ijbiomac.2019.04.163
web of science category Biochemistry & Molecular Biology; Chemistry, Applied; Polymer Science
subject category Biochemistry & Molecular Biology; Chemistry; Polymer Science
unique article identifier WOS:000482533000073
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journal analysis (jcr 2017):
journal impact factor 3.909
5 year journal impact factor 3.929
category normalized journal impact factor percentile 83.494
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