Surface functionalization of cuttlefish bone-derived biphasic calcium phosphate scaffolds with polymeric coatings
authors Neto, AS; Fonseca, AC; Abrantes, JCC; Coelho, JFJ; Ferreira, JMF
nationality International
journal MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
author keywords Cuttlefish bone; Hydrothermal transformation; Biphasic calcium phosphate; Ion doping; Polymeric coatings
keywords POLY(ESTER AMIDE)S; HYDROXYAPATITE SCAFFOLD; POROUS HYDROXYAPATITE; MECHANICAL-PROPERTIES; IN-VITRO; TISSUE; CERAMICS; MORPHOLOGY; DEFECTS; PEPTIDE
abstract Cuttlefish bone (CB) has been explored as biomaterial in the bone tissue-engineering field due to its unique porous structure and capacity of the aragonite mineral to be hydrothermally converted into calcium phosphates (CaPs). In the present study, undoped and ion (Sr2+, Mg2+ and/or Zn2+) doped biphasic calcium phosphate (BCP) scaffolds were prepared by hydrothermal transformation (HT, 200 degrees C, 24 h) of CB. The obtained scaffolds were sintered and then coated with two commercial polymers, poly(epsilon-caprolactone) (PCL) or poly(DL-lactide) (PDLA), and with two synthesized ones, a poly(ester amide) (PEA) or a poly(ester urea) (PEU) in order to improve their compressive strength. The scaffolds were characterized by X-ray diffraction (XRD) coupled with structural Rietveld refinement, Fourier transform infrared (FTIR) spectroscopy, and scanning electron microscopy (SEM). The results demonstrate that CB could be entirely transformed into BCPs in the presence or absence of doping elements. The initial CB structure was preserved and the polymeric coatings did not jeopardize the interconnected porous structure. Furthermore, the polymeric coatings enhanced the compressive strength of the scaffolds. The in vitro bio-mineralization upon immersing the scaffolds into simulated body fluid (SBF) demonstrated the formation of bone-like apatite surface layers in both uncoated and coated scaffolds. Overall, the produced scaffolds exhibit promising properties for bone tissue engineering applications.
publisher ELSEVIER
issn 0928-4931
isbn 1873-0191
year published 2019
volume 105
digital object identifier (doi) 10.1016/j.msec.2019.110014
web of science category Materials Science, Biomaterials
subject category Materials Science
unique article identifier WOS:000490044700025
  ciceco authors
  impact metrics
journal analysis (jcr 2019):
journal impact factor 5.88
5 year journal impact factor 5.364
category normalized journal impact factor percentile 82.895
dimensions (citation analysis):
altmetrics (social interaction):



 


Sponsors

1suponsers_list_ciceco.jpg