Canonical DNA minor groove insertion of bisbenzamidine-Ru(ii) complexes with chiral selectivity
authors Sanchez, MI; Rama, G; Calo-Lapido, R; Ucar, K; Lincoln, P; Lopez, MV; Melle-Franco, M; Mascarenas, JL; Vazquez, ME
nationality International
journal CHEMICAL SCIENCE
keywords MOLECULAR LIGHT SWITCH; METAL-COMPLEXES; RUTHENIUM(II) COMPLEXES; POLYPYRIDYL COMPLEXES; BINDING GEOMETRIES; LINEAR DICHROISM; BINDERS; LIGAND; PHOTOOXIDATION; INTERCALATION
abstract We report the first Ru(ii) coordination compounds that interact with DNA through a canonical minor groove insertion mode and with selectivity for A/T rich sites. This was made possible by integrating a bis-benzamidine minor groove DNA-binding agent with a ruthenium(ii) complex. Importantly, one of the enantiomers (Delta-[Ru(bpy)(2)b4bpy](2+), Delta-4Ru) shows a considerably higher DNA affinity than the parent organic ligand and the other enantiomer, particularly for the AATT sequence, while the other enantiomer preferentially targets long AAATTT sites with overall lower affinity. Finally, we demonstrate that the photophysical properties of these new binders can be exploited for DNA cleavage using visible light.
publisher ROYAL SOC CHEMISTRY
issn 2041-6520
year published 2019
volume 10
issue 37
beginning page 8668
ending page 8674
digital object identifier (doi) 10.1039/c9sc03053k
web of science category Chemistry, Multidisciplinary
subject category Chemistry
unique article identifier WOS:000487674500016
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journal impact factor 9.063
5 year journal impact factor 8.757
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